Results 151 to 160 of about 8,642,738 (340)

Writing a game-book in the classroom: a didactic project in lower secondary school

open access: yesItaliano a scuola
This paper reports on a didactic project that involved classes of grade 6 (first year) and 8 (third year) students of a lower secondary school. The project proposed the collaborative writing of a book-game with the aim of developing their writing, word ...
Linda De Siena
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Effects of ADHD on Writing Composition Product and Process in School-Age Students

open access: yesJournal of Attention Disorders, 2020
C. Rodríguez   +4 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Development of an Interactive E-book based on the ARCS Model to Improve Students' Arabic Writing Skills

open access: yesJurnal Al Bayan: Jurnal Jurusan Pendidikan Bahasa Arab
Arabic writing skill is the most difficult skill where many students are weak in this skill and the available teaching materials are less engaging. Therefore development of teaching materials based on the ARCS model was needed to help improve students ...
Indaha Nur Wahyuni   +3 more
doaj   +1 more source

From writing under production to the finished product

open access: yes, 2015
The study of manuscripts allows us to analyze the initial materialization of textuality, that is, the way in which text mass/material is built up, then the way in which an actual text is constructed that can then be turned into a book. This issue raises several questions: By what process are the enunciative forms constructed? Given the diachrony of the
openaire   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy