Results 221 to 230 of about 243,189 (262)

HMGB1 binds to and disrupts the hairpin structure of RNA15 and inhibits toll-like receptor activation. [PDF]

J Biol Chem
Lin C, Li P, Savitskaya AG, Lyukmanova E, Goncharuk SA, Mineev KS, Du X, Wang Y, Wang X.   +8 more
europepmc   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Host-Guest Interactions Enhance Charge Transport across Single Cyclodextrin/Azobenzene Complex Junction. [PDF]

J Am Chem Soc
Han S, Zhao J, Naskar S, Wu D, Herrmann C, Xia J, Li H.   +6 more
europepmc   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Enhancing both the Intensities and Resolution of ¹⁹F NMR Spectra of PFAS through Band-Selective Homonuclear Decoupling. [PDF]

Anal Chem
Rotzinger M, Müller V, Macher A, Feldmann J, Zangger K.   +4 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

The CHOVE-CHUVA Earth observation platform to monitor socio-environmental dynamics in Mato Grosso, Brazil. [PDF]

Sci Rep
Arvor D, Denize J, Rouxel L, Dubreuil V, Ribeiro UM, Funatsu BM, Betbeder J, Bégué A, Silgueiro V, da Silva CA, Dias AP, Simões M, Ferraz RPD, Kuchler P, Bellec A.   +14 more
europepmc   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Dual-Emitting Cyclometalated Platinum Compounds with Isocyanide Ligands. [PDF]

ACS Omega
Anderson CM, Greenberg MW, LaFratta CN, Lum RH, Oppenheimer EI, Duplessis TS, Tulloch KM, Tanski JM.   +7 more
europepmc   +1 more source