Results 131 to 140 of about 8,361,536 (279)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

كلمة العدد

مجلة كلية الشريعة والدراسات الإسلامية, 2019
ojsadmin production
doaj   +4 more sources

Orbital - Vol. 5 No. 2 - April-June 2013

Orbital: The Electronic Journal of Chemistry, 2013
Orbital Production
doaj  

Safety evaluation of the food enzyme glucan 1,4-α-glucosidase from the non-genetically modified <i>Aspergillus niger</i> strain AE-GN. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Andreoli C, Terron A, Cavanna D, Kovalkovicova N, Aguilera J, Andryszkiewicz M, de Sousa RF, Liu Y.   +20 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Orbital - Vol. 4 No. 3 - July-September 2012

Orbital: The Electronic Journal of Chemistry, 2012
Orbital Production
doaj  

Masting Breakdown in European Beech Reduces Fitness Benefits of Masting, Partly Explained by Climate Change. [PDF]

Ecol Evol
Jantzen CC, Burant JB, Gamelon M, Bakker ES, Visser ME.   +4 more
europepmc   +1 more source

Production preparation methodology in Swedish metal working industry - a State of the Art investigation

, 2008
This article presents a brief state of the art in the Swedish metal working industry regarding the production preparation process for the machine centre. The article is based on a relationship model from which a questionnaire was developed.
Beno, Tomas, Pejryd, Lars, Anderberg, Staffan   +2 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Climate Warming Will Reduce Boreal Forest Litterfall, but the Response Differs Among Plant Functional Types. [PDF]

Ecol Evol
Thu WP, Alcantara MJM, Dossa GGO, Thompson J, Schaefer D.   +4 more
europepmc   +1 more source