Results 41 to 50 of about 447,866 (328)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The oil & gas upstream cycle: Exploration activity [PDF]
EPJ Web of Conferences, 2020 Eni operates in all areas, from its traditional oil, gas and chemical businesses to renewable energy resources, through its business units and companies. Significant investments are also dedicated to research and development.
Craig J., Quagliaroli F.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Characterisation framework of key policy, regulatory and governance dynamics and impacts upon European food value chains: Fairer trading practices, food integrity, and sustainability collaborations. : VALUMICS project “Understanding Food Value Chains and Network Dynamics” funded by EU Horizon 2020 G.A. No 727243. Deliverable D3.3 [PDF]
, 2019 The report provides a framework that categorises the different European Union (EU) policies, laws and governance actions identified as impacting upon food value chains in the defined areas of: fairer trading practices, food integrity (food safety and ...
Barling, David +3 more
core +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Farm and Non-Farm Income Diversification Activities among Rural Households in Southeast, Nigeria
Journal of Agricultural Extension, 2019 The study assessed farm and non-farm income diversification activities among rural households in Southeast, Nigeria. Purposive and multi-stage random sampling techniques were used to collection data from three hundred and sixty (360) rural households ...
Ngozi Ekunyi Odoh +3 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Effects of covid-19 on the livelihoods of rural women in Ethiopia
CABI Agriculture and Bioscience, 2023 Background The COVID-19 pandemic has had an impact on people’s lives and economic activities. Women are expected to bear the impact of the impact because they are over-represented in affected sectors on the front lines of the pandemic’s response. However,
Samuel Tadesse Adisalem +1 more
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Power Producer Production Valuation
Acta Polytechnica, 2008 The ongoing developments in the electricity market, in particular the establishment of the Prague Energy Exchange (PXE) and the associated transfer from campaign-driven sale to continuous trading, represent a significant change for power companies ...
M. Kněžek
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