Results 51 to 60 of about 2,768,371 (268)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

PHYLOGENETIC AND HISTOPATHOLOGICAL CHARACTERIZATION OF NEWCASTLE DISEASE VIRUSES REVEALS HIGH PREVALENCE OF VERY VIRULENT STRAINS OF GENOTYPE VIID IN EGYPT [PDF]

Assiut Veterinary Medical Journal, 2016
Newcastle disease virus (NDV) is a highly contagious disease in poultry, also considered as a major challenge for the commercial and traditional poultry industry in Egypt. In this study clinicopathological and immunohistochemistry examination of fourteen
NAGLAA HAGAG, ALY ZANATY, MOHAMED SOLIMAN, MAHMOUD SAIED, A. ARAFA, M.K. HASSAN   +5 more
doaj   +1 more source

Avian influenza virus surveillance in migratory birds in Egypt revealed a novel reassortant H6N2 subtype

Avian Research, 2019
Background Avian influenza viruses (AIVs) have been identified from more than 100 different species of wild birds around the globe. Wild migratory birds can act as potential spreaders for AIVs to domestic birds between different countries.
Ali M. Zanaty, Ahmed M. Erfan, Wessam H. Mady, Fatma Amer, Ahmed A. Nour, Neveen Rabie, Mohamed Samy, Abdullah A. Selim, Wafaa M. M. Hassan, Mahmoud M. Naguib   +9 more
doaj   +1 more source

GENETIC CHARACTERISTICS OF INFECTIOUS BURSAL DISEASE VIRUS IN EGYPT FROM 2012 TO 2014 [PDF]

Assiut Veterinary Medical Journal, 2015
The infectious bursal disease virus (IBDV) is a continuing serious problem facing poultry industry in Egypt.  In this study, 24 bursae samples collected from different broiler flocks (from Giza, Dakahleya, Ismailia, Damietta and Alexanderia) experiencing
NAGLAA HAGAG, MOHAMED A. SOLIMAN, ABDEL SATAR ARAFA, ALI ZANATY, AHMED M. ERFAN, MOHAMED K. HASAN   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Managing Disruptions in Production with Machine Learning

Proceedings of the Conference on Production Systems and Logistics, 2020
Changing customer demands lead to increasing product varieties and decreasing delivery times, which in turn pose great challenges for production companies.
Samsonov, Vladimir, Enslin, Christmarie, Lütkehoff, Ben, Steinlein, Felix, Lütticke, Daniel, Stich, Volker   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Coupling order release methods with autonomous control methods – an assessment of potentials by literature review and discrete event simulation

International Journal of Production Management and Engineering, 2015
Production planning and control faces increasing uncertainty, dynamics and complexity. Autonomous control methods proved themselves as a promising approach for coping with these challenges.
Sebastian Grundstein, S. Schukraft, B. Scholz-Reiter, M. Freitag   +3 more
doaj   +1 more source