Results 151 to 160 of about 13,118,916 (332)
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A framework for reconfigurable production line changeover task planning based on large language model. [PDF]
Hou J, Yan L, Qiang H.
europepmc +1 more source
Deployment of edge-lightweight AI vertical models in multimodal anomaly detection and energy optimization of tech-long production line [PDF]
Xiaoman Wu +3 more
openalex +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Methicillin-resistant Staphylococcus aureus along the beef production line: Phenotypic resistance and mecA phylogeny in two ethiopian municipal abattoirs. [PDF]
Abie S +24 more
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
This project is based on designing a production line for a newly introduced product by I.E.E Company. Design of this production line consists of: Design of physical layout of the line, development of different systems to control the flow of material ...
Ejabat, Morteza
core

