Results 51 to 60 of about 13,645,076 (329)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Aprendizaje activo y desempeño del estudiante: diseño de un curso de dirección de la producción (Active learning methods and student performance: A design of a production management course)

WPOM : Working Papers on Operations Management, 2012
El diseño de un curso requiere utilizar un modelo de referencia que integre los diferentes elementos que lo forman, siendo función del profesor dar coherencia a estos elementos. El objetivo de este trabajo es revisar los principales componentes de diseño
Maria J. Oltra Mestre, Cristina García Palao, Marisa Flor Peris, Montserrat Boronat Navarro   +3 more
doaj   +1 more source

Production planning and scheduling with big data under resource and capacity constraints

İzmir İktisat Dergisi, 2021
Büyük veri, işletmelerin iç yapısında biriken veya çeşitli dış kaynaklardan toplanan verilerin derlenmesi, depolanması, düzenlenmesi ve analiz edilmesiyle anlamlı bilgiler ortaya çıkararak, işletmeler için fayda yaratabilmektedir.
Göktürk Akın, Burcu Akın
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

EARNED VALUE ANALYSIS, IMPLEMENTATION BARRIERS, AND MATURITY LEVEL IN OIL & GAS PRODUCTION

South African Journal of Industrial Engineering, 2019
Poor performance measurement practices in the oil and gas industry can cause project cost overruns, schedule delays, and scope increases. Earned value management, as an integrated project planning and control method measuring cost and schedule ...
Zhan, Zhaoxi , Wang, Chen , Yap, Jeffrey Boon Hui , Samsudin, Shaharudin , Abdul-Rahman, Hamzah   +4 more
doaj   +1 more source

Methods for Management of Soilborne Diseases in Crop Production

Agriculture, 2020
The significant problems caused by soilborne pathogens in crop production worldwide include reduced crop performance, decreased yield, and higher production costs. In many parts of the world, methyl bromide was extensively used to control these pathogens
M. Panth, Samuel C. Hassler, F. Baysal-Gurel   +2 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

PRODUCTION MANAGEMENT AND VALUE CHAIN OF CORN COMMODITY

Russian Journal of Agricultural and Socio-Economic Sciences, 2020
This study aims to analyze the management of corn production and farming, analyze the corn value chain, analyze the difference in marketing margins between the corn commodity value chain actors, and analyze the marketing efficiency among value chain ...
Dwijatenaya I.B.M.A., Raden I., Thamrin, Damayanti A.   +3 more
doaj   +1 more source