Results 41 to 50 of about 776,441 (307)

AI and OR in management of operations: history and trends [PDF]

open access: yes, 2007
The last decade has seen a considerable growth in the use of Artificial Intelligence (AI) for operations management with the aim of finding solutions to problems that are increasing in complexity and scale.
Kobbacy, KAH, Rasmy, MH, Vadera, S
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Optimising economic, environmental, and social objectives: a goal-programming approach in the food sector [PDF]

open access: yes, 2010
The business-decision environment is increasingly complicated by the emergence of competing economic, environmental, and social goals, a notion typified by the current pressures of global economic instability and climate-change targets.
Oglethorpe, David
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

A Bi-objective Model for Mineral Supply Chain Network Design Considering Social Responsibility and solving by a Novel Fuzzy Multi-choice Goal Programming method [PDF]

open access: yesInternational Journal of Industrial Engineering and Production Research, 2023
The main objective of this research is effective planning as well as greener production and distribution of mineral products in supply chain network.
Fatemeh Hajisoltani   +2 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Generation planning for power companies with hybrid production technologies under multiple renewable energy policies

open access: yesRenewable and Sustainable Energy Reviews, 2023
Increased use of environmentally friendly and energy-efficient transportation, such as electric vehicles, results in increased demand for power supply, putting pressure on the electricity infrastructure. One of the key challenges facing power companies operating within this context is effectively planning power production across multiple production ...
Qiao Peng   +4 more
openaire   +3 more sources

Sensitivity of multi-product two-stage economic lotsizing models and their dependency on change-over and product cost ratio's [PDF]

open access: yes, 2010
This study considers the production and inventory management problem of a two-stage semi-process production system. In case both production stages are physically connected it is obvious that materials are forced to flow.
Aghezzaf, El-Houssaine   +2 more
core  

Re-reengineering the dream: agility as competitive adaptability [PDF]

open access: yes, 2014
Organizational adaptation and transformative change management in technology-based organizations is explored in the context of collaborative alliances.
Allan F. McLay
core   +1 more source

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