Results 61 to 70 of about 776,441 (307)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pan-European backcasting exercise, enriched with regional perspective, and including a list of short-term policy options [PDF]

, 2010
This deliverable reports on the results of the third and final pan-European stakeholder meeting and secondly, on the enrichment with a Pilot Area and regional perspective.
Bärlund, I., Dubel, A., Kok, K., Sendzimir, J., Vliet, M., van   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Food System and Food Security Study for the City of Cape Town [PDF]

, 2014
Food insecurity is a critical, but poorly understood, challenge for the health and development of Capetonians. Food insecurity is often imagined as hunger, but it is far broader than that.
Battersby, Jane, Crush, Jonathan, Haysom, Gareth, McLachlan, Milla, Tawodzera, Godfrey   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Pricing and recovery planning for demanufacturing operations with multiple used products and multiple reusable components

Computers & Industrial Engineering, 2010
In this study, we consider a pricing and recovery planning problem encountered in demanufacturing where multiple types of reusable components can be recovered from multiple used product quality groups. The problem is to maximize the net profit of the demanufacturer by characterizing the optimal acquisition prices of the used products and selling prices
Department of Industrial and Systems Engineering, University of Florida, Gainesville, FL 32611-6595, USA ( host institution ), Karakayalı, İ. ( author ), Emir-Farinas, H. ( author ), Akçalı, E. ( author )   +3 more
openaire   +2 more sources

Inventory drivers in a pharmaceutical supply chain [PDF]

, 2017
In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent ...
Masvidal Andreu, Clara
core   +1 more source

Improved resource efficiency and cascading utilisation of renewable materials [PDF]

, 2015
In light of various environmental problems and challenges concerning resource allocation, the utilisation of renewable resources is increasingly important for the efficient use of raw materials.
Geldermann, Jutta, Kolbe, Lutz M., Krause, Andreas, Mai, Carsten, Militz, Holger, Osburg, Victoria Sophie, Schumann, Matthias, Schöbel, Anita, Toporowski, Waldemar, Westphal, Stephan   +9 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Incorporating an expedited rate, rework, and a multi-shipment policy into a multi-item stock refilling system

Operations Research Perspectives, 2019
Facing harsh competition in global marketplaces, management must construct the best possible supply chains to meet client requirements of quality, timely, and diverse products.
Singa Wang Chiu, Cheng-Sian Wu, Chao-Tang Tseng   +2 more
doaj   +1 more source