Results 231 to 240 of about 243,235 (310)

The Use of Stem Cells in Assisted Reproduction. [PDF]

J Clin Med
Szeliga A, Duszewska A, Unogu C, Smolarczyk R, Bochynska S, Bala G, Meczekalski B, Adashi EY.   +7 more
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

HMGB1 binds to and disrupts the hairpin structure of RNA15 and inhibits toll-like receptor activation. [PDF]

J Biol Chem
Lin C, Li P, Savitskaya AG, Lyukmanova E, Goncharuk SA, Mineev KS, Du X, Wang Y, Wang X.   +8 more
europepmc   +1 more source

Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy

Advanced Science, EarlyView.
A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao, Shan Qiao, Jie Bai, Jingjing Zhang, Zhiqin Xi, Zhenzhen Li, Xuelin Zhan, Ying Zhang, Xiaotong Yu, Yao Chen, Yijin Liu   +10 more
wiley   +1 more source

Host-Guest Interactions Enhance Charge Transport across Single Cyclodextrin/Azobenzene Complex Junction. [PDF]

J Am Chem Soc
Han S, Zhao J, Naskar S, Wu D, Herrmann C, Xia J, Li H.   +6 more
europepmc   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Enhancing both the Intensities and Resolution of ¹⁹F NMR Spectra of PFAS through Band-Selective Homonuclear Decoupling. [PDF]

Anal Chem
Rotzinger M, Müller V, Macher A, Feldmann J, Zangger K.   +4 more
europepmc   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

The CHOVE-CHUVA Earth observation platform to monitor socio-environmental dynamics in Mato Grosso, Brazil. [PDF]

Sci Rep
Arvor D, Denize J, Rouxel L, Dubreuil V, Ribeiro UM, Funatsu BM, Betbeder J, Bégué A, Silgueiro V, da Silva CA, Dias AP, Simões M, Ferraz RPD, Kuchler P, Bellec A.   +14 more
europepmc   +1 more source