Results 171 to 180 of about 1,415,684 (317)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Aggregate Milk Supply Response to the Milk Income Loss Contract Program

open access: yes
This research tests for changes in aggregate milk production due to the operation of the Milk Income Loss Contract (MILC) program since 2002. Aggregate production is decomposed into the size of the dairy herd and milk production per cow.
Anderson, David P.   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

BEYOND THE DETERMINISTIC: A STOCHASTIC EXTENSION TO THE MARINE CORPS ADVANCED PRODUCTION PLAN MODEL (MCAPPM)

open access: yes
In March 2025, the Marine Corps Advanced Production Plan Model (MCAPPM)—a fixed inventory Markov model aimed at increasing the United States Marine Corps (USMC) production plan accuracy—was published as an NPS thesis by Captain Brian Riddle USMC. Riddle (
Viehdorfer, Richard F.
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Computer Optimization of Steam Production

open access: yes, 1982
As fuel costs continued to rise sharply during the 1970' s, the staff at Exxon's Benicia Refinery realized there was a growing economic incentive to optimize the production of high pressure steam.
Todd, C. H.
core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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