A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Improving the Flexibility of Production Scheduling in Flat Steel Production Through Standard and AI-Based Approaches: Challenges and Perspectives [PDF]
, 2021 Vincenzo Iannino +10 more
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Large-Scale Customized Production Scheduling of Multiagent-Based Medical 3D Printing. [PDF]
Comput Intell Neurosci, 2022 He J, Wu J, Zhang Y, Wang Y, He H.
europepmc +1 more source
Constraint monitoring in TOSCA [PDF]
The Job-Shop Scheduling Problem (JSSP) deals with the allocation of resources over time to factory operations. Allocations are subject to various constraints (e.g., production precedence relationships, factory capacity constraints, and limits on the ...
Beck, Howard
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Application of Blockchain Technology in Production Scheduling and Management of Human Resources Competencies. [PDF]
Sensors (Basel), 2022 Balon B, Kalinowski K, Paprocka I.
europepmc +1 more source
Evaluation of hydropower upgrade projects - a real options approach [PDF]
When evaluating whether to refurbish existing hydropower plants or invest in a new power plant, there are two important aspects to take into consideration. These are the capacity chosen for the production facilities and the timing of the investment. This
Elverhøi, Morten +5 more
core +1 more source
Minimisation of energy consumption variance for multi-process manufacturing lines through genetic algorithm manipulation of production schedule [PDF]
, 2015 Typical manufacturing scheduling algorithms do not consider the energy consumption of each job, or its variance, when they generate a production schedule.
Duerden, Christopher James +3 more
core