Results 121 to 130 of about 375,167 (310)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Combined Algorithm Using Both the MINLP Model and Approximated MILP Model for PVC Production Scheduling. [PDF]

ACS Omega, 2022
Su J, Wang Y, Gao X.
europepmc   +1 more source

Uncertainty management by relaxation of conflicting constraints in production process scheduling [PDF]

Mathematical-analytical methods as used in Operations Research approaches are often insufficient for scheduling problems. This is due to three reasons: the combinatorial complexity of the search space, conflicting objectives for production optimization ...
Dorn, Juergen, Slany, Wolfgang, Stary, Christian   +2 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Review on Multi‑objective Dynamic Scheduling Methods for Flexible Job Shops and Application in Aviation Manufacturing

Transactions of Nanjing University of Aeronautics and Astronautics
Intelligent production is an important development direction in intelligent manufacturing， with intelligent factories playing a crucial role in promoting intelligent production.
MA Yajie, JIANG Bin, GUAN Li, CHEN Lijun, HUANG Binda, CHEN Zhi   +5 more
doaj   +1 more source

Workforce planning and production scheduling in a reconfigurable manufacturing system facing the COVID-19 pandemic. [PDF]

J Manuf Syst, 2022
Vahedi-Nouri B, Tavakkoli-Moghaddam R, Hanzálek Z, Dolgui A.   +3 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Evaluation of hydropower upgrade projects - a real options approach [PDF]

When evaluating whether to refurbish existing hydropower plants or invest in a new power plant, there are two important aspects to take into consideration. These are the capacity chosen for the production facilities and the timing of the investment. This
Elverhøi, Morten, Fleten, Stein-Erik, Fuss, Sabine, Heggedal, Ane Marte, Szolgayova, Jana, Troland, Ole Christian   +5 more
core   +1 more source

Minimisation of energy consumption variance for multi-process manufacturing lines through genetic algorithm manipulation of production schedule [PDF]

, 2015
Typical manufacturing scheduling algorithms do not consider the energy consumption of each job, or its variance, when they generate a production schedule.
Duerden, Christopher James, Hall, Geoff, Howe, Joseph Mark, Shark, Lik-Kwan   +3 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source