Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Optimizing energy, downtime, and throughput in footwear production through machine learning. [PDF]
Sudhakar PK, Muthucumaraswamy R.
europepmc +1 more source
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Optimization of machine tool processing scheduling based on differential evolution algorithm. [PDF]
Zhang Y, Zhang M.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Dynamic multi objective task scheduling in cloud computing using reinforcement learning for energy and cost optimization. [PDF]
Yu X, Mi J, Tang L, Long L, Qin X.
europepmc +1 more source
Irrigation schedules and production of processed tomatoes on the San Joaquin Westside
F Aljibury, D May
openalex +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
A robot scheduling method based on rMAPPO for H-beam riveting and welding work cell. [PDF]
Zheng J +7 more
europepmc +1 more source
A case study for spreadsheet based production scheduling
B. Scott Perrin +1 more
openalex +1 more source

