Results 51 to 60 of about 381,564 (342)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Production/maintenance cooperative scheduling using multi-agents and fuzzy logic [PDF]

, 2002
Within companies, production is directly concerned with the manufacturing schedule, but other services like sales, maintenance, purchasing or workforce management should also have an influence on this schedule.
AYEL J., B. Archimède, B. Grabot, BARNETT K. W., BASKER B. A., DENIAUD S., Fox M. S., HAMMER M., ISHII H., MIYASHITA K., PARUNAK H. V. D., PATE-CORNELL M. E., SAAD A., SHEN W., SMITH S. F., T. Coudert   +15 more
core   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Order scheduling optimization in manufacturing enterprises based on MDP and dynamic programming

Scientific Reports, 2023
In the era of Industry 4.0, order scheduling is a crucial link in the production of manufacturing enterprises. In view of order scheduling in manufacturing enterprises, a finite horizon Markov decision process model is proposed in this work based on two ...
Qiqige Wulan
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Integrated Production and Transportation Scheduling Method in Hybrid Flow Shop

Chinese Journal of Mechanical Engineering, 2022
The connection between production scheduling and transportation scheduling is getting closer in smart manufacturing system, and both of those problems are summarized as NP-hard problems.
Wangming Li, Dong Han, Liang Gao, Xinyu Li, Yang Li   +4 more
doaj   +1 more source

Synthesis and Stochastic Assessment of Cost-Optimal Schedules [PDF]

, 2006
We present a novel approach to synthesize good schedules for a class of scheduling problems that is slightly more general than the scheduling problem FJm,a|gpr,r_j,d_j|early/tardy.
Bohnenkamp, H.C., Hermanns, H., Hurink, J.L., Jansen, D.N., Mader, A.H., Usenko, Y.S.   +5 more
core   +2 more sources

Power efficient job scheduling by predicting the impact of processor manufacturing variability [PDF]

, 2019
Modern CPUs suffer from performance and power consumption variability due to the manufacturing process. As a result, systems that do not consider such variability caused by manufacturing issues lead to performance degradations and wasted power.
Casas, Marc, Chasapis, Dimitrios, Moreto Planas, Miquel, Rountree, Barry, Schulz, Martin, Valero Cortés, Mateo   +5 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source