Results 51 to 60 of about 6,566,838 (299)
Reasonable production scheduling plays a vital role in the production of precast component factories. However, previous static scheduling models no longer fit actual production.
Minhao Ruan, Feng Xu
doaj +1 more source
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
The pulsating assembly line is widely used in modern manufacturing, particularly in high-precision industries such as aerospace, where it greatly enhances production efficiency.
Hailong Song +4 more
doaj +1 more source
Integrated Production and Transportation Scheduling Method in Hybrid Flow Shop
The connection between production scheduling and transportation scheduling is getting closer in smart manufacturing system, and both of those problems are summarized as NP-hard problems.
Wangming Li +4 more
doaj +1 more source
A Hybrid Metaheuristic for the Unrelated Parallel Machine Scheduling Problem
The unrelated parallel machine scheduling problem aims to assign jobs to independent machines with sequence-dependent setup times so that the makespan is minimized.
Dung-Ying Lin, Tzu-Yun Huang
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
A Customized IMOEA/D for Bi-Objective Single-Machine Scheduling with Adaptive Preventive Maintenance
The prolonged operation of machines in the production process can lead to continuous deterioration or even failure, and the necessary maintenance measures can alleviate the above negative effects.
Na Wang, Fang Wu, Hongfeng Wang
doaj +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Protein kinase FAM20C—when subcellular localization matters
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
Hybrid Flow Shop Scheduling Problems Using Improved Fireworks Algorithm for Permutation
Prior studies are lacking which address permutation flow shop scheduling problems and hybrid flow shop scheduling problems together to help firms find the optimized scheduling strategy.
Xuelian Pang +4 more
doaj +1 more source

