Results 71 to 80 of about 847,146 (267)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Continuous production of California timber can yield profitable returns

open access: yesCalifornia Agriculture, 1947
Two types of landowner are affected by the emerging and increasing opportunities for the management of timber on a continuous basis as a permanent and profitable business—the industrial lumbermen and the farmer or other rural proprietor of a small tract ...
P Barr
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Silencing of GhSHP1 hindered flowering and boll cracking in upland cotton

open access: yesFrontiers in Plant Science
The opening of cotton bolls is an important characteristic that influences the precocity of cotton. In the field, farmers often use chemical defoliants to induce cotton leaves to fall off earlier, thus accelerating the cracking of cotton bolls.
Wenjuan Xu   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Dynamics of lentil (Lens culinaris) production and trade: Global scenario and Indian interdependence

open access: yesThe Indian Journal of Agricultural Sciences
Increasing pulse production is one of the national priorities for food and nutritional security of India. In this context, incremental changes in pulse production can play a pivotal role.
UMA SAH   +7 more
doaj   +1 more source

Flagella disruption in Bacillus subtilis increases amylase production yield. [PDF]

open access: yesMicrob Cell Fact, 2022
Fehler AO   +6 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

The structure of production in Romanian agriculture - the gap between the EU27

open access: yesEkonomika Poljoprivrede (1979), 2010
The paper aims to capture the differences between the production structures of different countries and differences existing in some respects, between Romania and EU.
Radu Voicu   +2 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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