Results 71 to 80 of about 266,637 (207)

Le dromadaire et le cochon : deux visions opposées de l'élevage ? [PDF]

open access: yes, 2011
Le dromadaire et le cochon sont deux espèces d'élevage emblématiques d'un gradient allant de l'extensif à l'intensif et se déclinant sur divers registres a priori exclusifs. Pourtant, malgré les différences fondamentales de ces deux espèces, tant sur les
Faye, Bernard, Porphyre, Vincent
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Anthelmintic Activity, Cytotoxicity, and Phytochemical Screening of Plants Used to Treat Digestive Parasitosis of Small Ruminants in Benin (West Africa). [PDF]

open access: yesAnimals (Basel), 2022
Tchetan E   +12 more
europepmc   +1 more source

Un outil simple de projection démographique pour estimer la productivité d'un cheptel : application à un cheptel bovin de la zone cotonnière au Mali-Sud [PDF]

open access: yes, 2011
International audienceL'article présente une interface développée sous forme de feuilles de tableur, appelée Dynmod (http://livtools.cirad.fr), permettant de réaliser des projections démographiques de cheptel de ruminants et d'estimer leur productivité ...
Ba, Alassane   +4 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Fractionation Coupled to Molecular Networking: Towards Identification of Anthelmintic Molecules in Terminalia leiocarpa (DC.) Baill. [PDF]

open access: yesMolecules, 2022
Tchetan E   +8 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Le conseil en élevage en milieu tropical [PDF]

open access: yes, 1999
Les contraintes propres aux pays tropicaux (illétrisme, logiques non marchandes, contextes sociologiques, faiblesse de l'encadrement, pauvreté) et le rôle multiple de l'activité d'élevage (sécurisation, capitalisation, diversification, intégration ...
Faye, Bernard, Lhoste, Philippe
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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