Results 71 to 80 of about 359,246 (179)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Utilisation des microorganismes dans l’hydrolyse des amyloïdes et des farines animales

, 2020
International audienceA la suite de l’interdiction des farines animales en alimentation animale, il est nécessaire de mettre au point des procédés simples et économiques pour les valoriser et les décontaminer vis-à-vis de la présence possible de prion ...
P. NEDKOV, Métro, F., J.M. CHOBERT, D. DORMONT, Bonch-Osmolovskaya, E., K. TSIROULNIKOV, Haertlé, T., T. HAERTLÉ, Grosclaude, J., Clayette, P., H. REZAEI, F. MÉTRO, J. GROSCLAUDE, Nedkov, P., Dormont, D., A. GODFROY, A. GOUSTEROVA, Gousterova, A., Chobert, J.M., Rezaei, Human, E. BONCH-OSMOLOVSKAYA, P. CLAYETTE, Tsiroulnikov, K., Godfroy, A., G. BARBIER, Cueff, V., Barbier, G., V. CUEFF   +27 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Des animaux plus robustes : un enjeu majeur pour le développement durable des productions animales nécessitant l'essor du phénotypage fin et à haut débit

, 2014
National audienceThe major challenge of animal phenotyping is to acquire systemic knowledge of farm animal robustness. This will allow responding to a double objective in terms of exploiting the variability of animal aptitudes: selection for major ...
Hocquette, Jean-François,, Hocquette, Jean-François, Bobe, Julien, B. CHARLEY, J.F. Hocquette, P.Y. LE BAIL, E. LE BIHAN-DUVAL, P. MORMÈDE, Charley, Bernard, Quéré, Pascale, Friggens, Nicolas Charles, J. BOBE, Bodin, Loys, Friggens, Nicolas, N.C., L. BODIN, Dourmad, Jean-Yves, F. PHOCAS, Le Bihan-Duval, Elisabeth, Schelcher, Francois, P. QUÉRÉ, Friggens, Nicolas,, Mormède, Pierre, Duval, Elisabeth, J.Y. DOURMAD, Le Bail, Pierre-Yves, Phocas, Florence, F. SCHELCHER, N.C. FRIGGENS   +27 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Éditorial — 30 ans pour les Rencontres autour des Recherches sur les Ruminants, quel bel âge !

Cet éditorial introduit le numéro 2 de 2025 de la revue INRAE Productions Animales consacré aux 30 ans des Rencontres autour des Recherches sur les Ruminants (3R)
Philippe MAUGUIN, Mauguin, Philippe, Joël MERCERON, Merceron, Joël   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Intégrer les changements d’échelle pour améliorer l’efficience des productions animales et réduire les rejets

, 2019
L’élevage est soumis à des défis considérables pour s’adapter au problème de compétition sur les ressources, notamment alimentaires, et aux problèmes environnementaux.
Faverdin, Philippe, Van Milgen, Jacob
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source