Results 61 to 70 of about 1,354,863 (284)

Productive knowledge, poverty and the entrepreneurial challenges of South African towns

open access: yesSouth African Journal of Science, 2018
Stagnant exports per capita and growing poverty in South Africa necessitated an examination of the links between the levels of productive knowledge (measured as enterprise richness), poverty (measured as Enterprise Dependency Indices) and entrepreneurial
Daan Toerien
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Knowledge-based industry and regional growth [PDF]

open access: yes, 2005
One of the most important but less understood phenomena in the beginning of the 21st century has been a shift toward knowledge-based economic activity in the comparative advantage of modern industrialized countries.
Park, Sam Ock
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

The effect of digital storytelling on learners` receptive and productive vocabulary knowledge

open access: yesAustralian Journal of Applied Linguistics
This study attempted to measure the effect of digital storytelling on learners' receptive and productive vocabulary knowledge. For this purpose, 48 intermediate English proficiency participants were divided into two equal groups: control and ...
Ali Al Ghaithi, Behnam Behforouz
doaj   +1 more source

Using Technology to Develop Preservice Teachers\u27 Reflective Thinking

open access: yes, 2007
Developing high-level reflection skills proves troublesome for some preservice teachers. To examine the potential of an online environment for increasing productive reflection, students in three sequential undergraduate education classes responded to ...
Dittrich, Charles   +3 more
core  

Time Trends for Livestock Production in Saskatchewan, Canada: 1905-2011 [PDF]

open access: yes, 2011
Saskatchewan, Canada, with a total land area of 651,900 km^2^, is one of the world’s most productive agricultural regions. A broad variety of livestock are raised in the province, including cattle, pigs, poultry, sheep/goats, llama, ostrich, elk ...
Kaya Forest, Sierra Rayne
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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