Results 51 to 60 of about 227,214 (238)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PRECARIZAÇÃO DO TRABALHO FEMININO: a realidade das mulheres no mundo do trabalho

Revista de Políticas Públicas, 2016
This article discusses about the precariousness of female employment in the context of productive capital restructuring. Emphasizes the socio - historical inequalities built between masculine and feminine, the sexual division of labor, and the ...
Sara Diniz Nascimento
doaj  

Desempenho de uma serraria com base na eficiência e na amostragem do trabalho

Floresta e Ambiente
O objetivo deste trabalho foi avaliar o desempenho de uma serraria de pequeno porte, localizada na região sul do Espírito Santo, processadora de madeira de eucalipto.
Djeison Cesar Batista, João Gabriel Missia da Silva, Rafael Bridi Corteletti   +2 more
doaj   +1 more source

Job Resources and Job Results: the Role of Productive Organizational Energy

Revista Psicologia, 2023
According to the Job Demands-Resources model, work performance is developed through the balance between job demands and resources. Based on this framework, the present study aimed to test the mediation of productive organizational energy in the ...
Larissa Gabardo-Martins, Evânia Silva Louro, Fernanda Settercerze Rodrigues, Filipi Junger Branco Brasil, Bruna Abreu Vieira, Ludimila Pereira Alves, Juliana da Silva Sanches Leão, Amanda Tinoco, Cláudio Eduardo dos Santos Costa Júnior   +8 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Restructuring production and work

, 1995
The paper analyzes the contemporary organizational restructuring of production and work and derives some salient implications for the labor market. The analysis focuses on the switch from occupational specialization at “Tayloristic” organizations to multi-tasking at “holistic” organizations.
Lindbeck, Assar, Snower, Dennis J.
openaire   +5 more sources