Results 261 to 270 of about 2,952,128 (360)

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

open access: yesAdvanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang   +9 more
wiley   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang   +6 more
wiley   +1 more source

TaPPR13, a Pentatricopeptide Repeat Protein Gene Activated by TaBZR2, Confers Drought Stress Tolerance by Enhancing the Antioxidant Defense System and Promoting Retrograde Signaling in Wheat (Triticum aestivum)

open access: yesAdvanced Science, EarlyView.
TaPPR13, a PPR protein family gene in wheat is activated by TaBZR2 to enhance drought stress tolerance and photosynthetic capacity. It achieves this by interacting with TaAOR1 and TaSIG5 to improve antioxidant defense and regulate chloroplast gene expression. Abstract The wheat (Triticum aestivum) brassinazole‐resistant 2 (TaBZR2) gene is identified as
Ze‐Hao Hou   +20 more
wiley   +1 more source

Resident Scholarly Activity and Productivity Outcomes Before and After Implementing a Structured Research Program: A Before-After Study. [PDF]

open access: yesAEM Educ Train
Krispin S   +8 more
europepmc   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

open access: yesAdvanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu   +13 more
wiley   +1 more source

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