Results 271 to 280 of about 2,952,128 (360)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Productivity Losses Due to Long-Term Back Problems in Working-Age Australians.

JAMA Netw Open
Docking SI, Ackerman IN, Buchbinder R, Zomer E, Liew D, Ademi Z.   +5 more
europepmc   +1 more source

Nutrient connectivity via seabirds enhances dynamic measures of coral reef ecosystem function. [PDF]

PLoS Biol
Benkwitt CE, Zora A, Ebrahim A, Govinden R, Lange ID, Evans S, Schulze M, Cotton E, Bennett L, Graham NAJ.   +9 more
europepmc   +1 more source

Sequence‐ and Docking‐Site‐Dependent Contributions to Multi‐Site Phosphorylation of an Intrinsically Disordered MAPK Substrate

Advanced Science, EarlyView.
Real‐time NMR spectroscopy is used to study JNK1‐dependent phosphorylation of the intrinsically disordered substrate JIP1, revealing eleven phosphosites with distinct phosphorylation efficiencies. The site‐specific phosphorylation rates are shown to be determined by both the sequence position of the phosphosites relative to the two kinase docking site ...
Thibault Orand, Elise Delaforge, Marion Chenal, Maud Tengo, Torsten Herrmann, Juan Cortés, Pau Bernadó, Malene Ringkjøbing Jensen   +7 more
wiley   +1 more source

Measuring Company Productivity: Handbook with Case Studies.

, 1962
Richard Perlman, John W. Kendrick, Daniel Creamer   +2 more
openalex   +2 more sources

Implantable Ion‐Selective Organic Electrochemical Transistors Enable Continuous, Long‐Term, and In Vivo Plant Monitoring

Advanced Science, EarlyView.
This work explores ion‐selective organic electrochemical transistors for real‐time, long‐term potassium monitoring in the xylem sap of living trees. This bioelectronic approach provides new insights into plant physiology and has the potential to revolutionize forest, agricultural, and ecological monitoring for smarter, more sustainable plant management.
Sanggil Han, Dalila Pasquini, Mathias Sorieul, Miguel H. Boratto, Luke Gatecliff, Alan Dickson, Suhyeon Jang, Stephanie Davy, George G. Malliaras, Yi Chen   +9 more
wiley   +1 more source

Including Productivity as an Element to Reflect Value of the Treatment: A Systematic Review of Published Health Economic Evaluations. [PDF]

Pharmacoecon Open
Mamiya H, Wattanakamolkul K, Li N, Wu DB, Hirozane M, Igarashi A.   +5 more
europepmc   +1 more source

Productivity in Sessile Algal Community of Japanese Mountain River

, 1961
Hiromu Kobayasi
openalex   +2 more sources

Storage Potential of Soil Functional Carbon Fractions in the World's Largest Plantations

Advanced Science, EarlyView.
Climate warming and drying increase the loss of mineral‐associated and particulate organic carbon during the conversion of natural forests to plantations. Based on a survey of the world's largest plantations, the study quantifies the soil carbon deficit in plantations and assesses benchmarks and targets for functional soil organic carbon, highlighting ...
Siyu Ren, Hui Wang, Tao Zhou, Chuankuan Wang, Zhenghu Zhou, Shirong Liu   +5 more
wiley   +1 more source

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities. [PDF]

Microb Cell Fact
Gamal A, El-Sayed ASA, Fikry E, Tawfeek N, El-Shafae AM, El-Domiaty MM.   +5 more
europepmc   +1 more source