Results 291 to 300 of about 2,952,128 (360)

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

open access: yesAdvanced Science, EarlyView.
In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li   +8 more
wiley   +1 more source

Florigen and Florigen‐Like Genes Regulate Temperature‐Responsive Flowering in Tomato

open access: yesAdvanced Science, EarlyView.
This study uncovers that FLOWERING LOCUS T‐Like 2 (FTL2) and SINGLE‐FLOWER TRUSS (SFT) antagonistically regulate temperature‐responsive flowering in the tomato shoot apical meristem. High temperature induces floral repressor FTL2, which directly inhibits SFT to delay short‐day floral transition, while SFT reciprocally inhibits FTL2 to promote flowering.
Jia Song   +8 more
wiley   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

open access: yesAdvanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang   +7 more
wiley   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen   +6 more
wiley   +1 more source

OSNRT1.1B‐OSCNGC14/16‐CA2+‐OSNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

open access: yesAdvanced Science, EarlyView.
OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang   +9 more
wiley   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

open access: yesAdvanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim   +7 more
wiley   +1 more source

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