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Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile+8 more
wiley +1 more source
Dynamic pattern of carbon balance in the forests of federal districts of the Russian Federation [PDF]
According to the data of the State Forest Registry and the archive materials of the State Forest Fund Account carbon budget of the forests of federal districts (FDs) of Russia was calculated for the years 1988–2015.
D.G. Zamolodchikov+2 more
doaj +1 more source
Labour Productivity Superstatistics
We discuss superstatistics theory of labour productivity. Productivity distribution across workers, firms and industrial sectors are studied empirically and found to obey power-distributions, in sharp contrast to the equilibrium theories of mainstream ...
Aoyama, Hideaki+3 more
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
Assessment of biomass of forest species using satellite images of high spatial resolution (on the example of the forest of Khanty-Mansi Autonomous Okrug) [PDF]
The paper describes assessment of spatial biomass of top wood layer based on combination of high-resolution Landsat-8 satellite images and selected ground forest inventory data measurements.
E.N. Sochilova+3 more
doaj +1 more source
WEB-BASED GIS FOR MAPPING FIRE REGIMES OF PECHORO-ILYCH RESERVE AND ITS ENVIRONS
The article is devoted to the description of the web-GIS for mapping fire regimes in the Pechora-Ilych reserve and its environs. The main purpose of the resource is to provide the results of mapping fire regimes in the designated area to a wide range of ...
A.S. Plotnikova, A.O. Kharitonova
doaj +1 more source
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi+2 more
wiley +1 more source
Background Being the product of the same environment, soil and vegetation are mutually associated with each other, but the relationships between edaphic properties and vegetation characteristics are still far from clear.
Natalia V. Lukina+14 more
doaj +1 more source
ABSTRACT Objective Spinal muscular atrophy (SMA) significantly impacts motor function. This study aimed to assess the persistent burden and unmet needs among currently treated patients with SMA and their caregivers. Methods Two complementary web‐based surveys were distributed in August 2024 among patients with SMA and their caregivers.
Julie A. Parsons+8 more
wiley +1 more source
Tele-Health Monitoring of Patient Wellness
The vital signs of chronically ill patients are monitored daily. The record flags when a specific vital sign is stable or when it trends into dangerous territory. Patients also self-assess their current state of well-being, i.e.
Sparks Ross Stewart, Okugami Chris
doaj +1 more source