Results 131 to 140 of about 270,461 (241)

Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. [PDF]

, 2019
BACKGROUND: Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied. OBJECTIVES: Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate ...
Ahmad, Faiz, Alió Saenz, Alessandra, Blume-Peytavi, Ulrike, Del Rosso, James, Gooderham, Melinda, Graeber, Michael, Johnson, Sandra, Lynde, Charles, Parish, Lawrence, Popp, Georg, Sanchez Colon, Nestor, Stein Gold, Linda, Tan, Jerry, Thiboutot, Diane, Weglovska, Jolanta, Weiss, Jonathan, Witkowska, Dagmara   +16 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

EXCHANGE RATE PASS-THROUGH TO DOMESTIC PRICES: THE CASE OF COLOMBIA [PDF]

This study uses an econometric framework based on an unrestricted vector autoregressive (VAR) model to study exchange rate pass-through to import, producer and consumer prices in Colombia. Exchange rate pass-through is shown to be incomplete.
Peter Rowland
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Vínculo público-privado como estrategia para el fortalecimiento del pequeño productor:

Pensamiento y Acción Interdisciplinaria, 2017
Tradicionalmente, han sido los sectores público y privado quienes han realizado acciones en beneficio de una de las actividades económicas más importantes de Chile, la agricultura.
Betsabé Rubilar Arriaza
doaj  

CIAT - gestores de innovación en agroindustria rural: el conocimiento del mercado como brújula para la innovación

, 2015
Los Gestores de Innovación en Agroindustria Rural (GIAR) son un mecanismo de co-innovación con enfoque de cadena productiva, que permite al pequeño productor y a las organizaciones locales organizar su trabajo, intercambiar conocimientos y fortalecer sus
Hurtado Bermúdez, Jhon J., Mosquera Echeverry, Erika Eliana   +1 more
core  

Determinación del costo de inversión y sostenimiento de un programa de transferencia de embriones para la asociación de ganaderos de Argelia, Valle del Cauca [PDF]

, 2016
El proyecto tiene como principal objetivo determinar el valor de la inversión que se debe realizar para establecer y sostener un programa de transferencia de embriones para beneficio de los miembros de la asociación de ganaderos de Argelia (Valle del ...
Osorio Buritica, Alejandro
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

TRÍADAS PUTUMAYENSES: RELACIONES PATRÓN-CLIENTE en la economía de la cocaína

Revista Colombiana de Antropología, 2006
ESTE TEXTO ANALIZA LAS RELACIONES DE PRODUCCIÓN DE COCA EN EL BAJO PUTUMAYO (Colombia) como relaciones de patrón-cliente. El artículo sostiene que el intercambio de muestras tangibles de buena voluntad entre los intermediarios, por muestras intangibles ...
OSCAR JANSSON
doaj