Results 131 to 140 of about 2,275 (257)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

[Ischemic stroke in dengue: Are we facing an immunomediated response? A case report] [PDF]

open access: yesRev Fac Cien Med Univ Nac Cordoba
Sala J   +3 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Young maize plants impact the bacterial community in Australian cotton-sown vertisol more than agricultural practices. [PDF]

open access: yesEnviron Microbiol Rep
Dendooven L   +8 more
europepmc   +1 more source

Tumores productores de inmunoglobulinas

open access: yes
Immunoglobulín-producing tumors in the dog are usually associated with lymphoproliferatiue disorders. The multiple myeloma is the most common and it is the more frequent cause of a monoclonal gammapathy. This tumor has a very low incidence and the diagnosis is quite difficult. The clínical signs sometimes are vague and non specific.
Font Utset, Artur   +3 more
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

[Moraxella spp. bacteremia in children attended in a hospital in southern Spain]. [PDF]

open access: yesRev Esp Quimioter
Vázquez-Pérez A   +3 more
europepmc   +1 more source

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