Results 81 to 90 of about 48,956 (252)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2002 El productor de cine se encuentra entre los "grandes olvidados" de la historia del séptimo arte. Su trabajo implica gran variedad de saberes y destrezas, tanto creativas como de gestión.
Pardo, A. (Alejandro)
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ficha del productor/taller. Taller pensamiento y creatividad.
, 2001 50 hojas : ilustraciones.El documento corresponde a las fichas productor / taller y fichas técnicas de los productos del oficio de la joyería en el departamento de Antioquia.Incluye fichas productor / taller.Incluye fichas técnicas de los productos ...
Díaz López, Lyda del Carmen, coordinadora diseño +1 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Normas de competencia del productor de plantones de café y especies asociadas.
, 2012 Normas de competencia del productor de plantones de café y especies ...
Sistema Nacional de Evaluación, Acreditación y Certificación de la Calidad Educativa - SINEACE
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Diseño de un mecanismo de gobierno para coordinar las compras de un productor a sus proveedores dentro de una cadena de suministro [PDF]
, 2019 220 páginasEste trabajo estudia el problema de coordinación de las compras entre un productor y sus proveedores, dentro de la cadena de suministro para un productor que tiene a una gama diversa de productos.
Vega Mejía, Germán Ricardo
core +1 more source