Results 201 to 210 of about 12,852,096 (349)
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Nature Biotechnology, 2016 Mingxun Wang, Jeremy J. Carver, Vanessa V. Phelan, Laura M. Sanchez, Neha Garg, Yao Peng, Don D. Nguyen, J. Watrous, Clifford A. Kapono, Tal Luzzatto-Knaan, Carla Porto, Amina Bouslimani, A. Melnik, Michael J. Meehan, Wei-Ting Liu, M. Crüsemann, Paul D. Boudreau, E. Esquenazi, Mario Sandoval-Calderón, R. Kersten, L. Pace, R. Quinn, Katherine R. Duncan, Cheng-Chih Hsu, D. Floros, R. Gavilán, Karin Kleigrewe, T. Northen, R. Dutton, D. Parrot, Erin E. Carlson, B. Aigle, C. F. Michelsen, L. Jelsbak, Christian Sohlenkamp, P. Pevzner, A. Edlund, J. McLean, J. Piel, B. Murphy, L. Gerwick, C. Liaw, Yu-Liang Yang, H. Humpf, M. Maansson, R. Keyzers, A. Sims, Andrew R. Johnson, A. Sidebottom, Brian E. Sedio, Andreas K. Klitgaard, Charles B. Larson, Cristopher A Boya P, Daniel Torres-Mendoza, D. Gonzalez, D. Silva, L. M. Marques, D. Demarque, E. Pociūtė, E. O’Neill, Enora Briand, Eric J. N. Helfrich, Eve A Granatosky, E. Glukhov, Florian Ryffel, H. Houson, H. Mohimani, Jenan J. Kharbush, Yi Zeng, J. Vorholt, Kenji L. Kurita, Pep Charusanti, K. McPhail, K. Nielsen, L. Vuong, Maryam Elfeki, Matthew F. Traxler, Niclas Engene, Nobuhiro Koyama, Oliver B. Vining, R. Baric, Ricardo R. Silva, Samantha J. Mascuch, S. Tomasi, Stefan Jenkins, V. Macherla, Thomas Hoffman, V. Agarwal, P. Williams, Jingqui Dai, R. Neupane, Joshua R. Gurr, A. M. C. Rodriguez, Anne Lamsa, Chen Zhang, Kathleen Dorrestein, B. Duggan, J. Almaliti, Pierre-Marie Allard, P. Phapale, Louis-Félix Nothias, T. Alexandrov, M. Litaudon, J. Wolfender, J. Kyle, T. Metz, Tyler Peryea, Dac-Trung Nguyen, Danielle Vanleer, P. Shinn, A. Jadhav, R. Müller, K. Waters, Wenyuan Shi, Xueting Liu, Lixin Zhang, R. Knight, P. Jensen, B. Palsson, K. Pogliano, Roger G. Linington, Marcelino Gutiérrez, N. Lopes, W. Gerwick, B. Moore, P. Dorrestein, N. Bandeira +126 moresemanticscholar +1 more sourceDetection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou +11 morewiley +1 more sourceRobust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen +13 morewiley +1 more sourceTargeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu +7 morewiley +1 more sourceKMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter +10 morewiley +1 more source