Results 11 to 20 of about 34,036 (135)

Portuguese Society of Ophthalmology and Portuguese Society of Human Genetics Joint Clinical Practice Guidelines for Genetic Testing in Inherited Retinal Dystrophies. [PDF]

Clin Genet
This study provides clinical practice guidelines to streamline genetic testing for inherited retinal dystrophies (IRDs), underscoring the critical role of molecular diagnosis in enhancing patient care. These recommendations aim to elevate diagnostic accuracy, guide therapeutic decisions, and ultimately improve patient outcomes, marking a significant ...
Marques JP, Soares CA, Carvalho AL, Estrela-Silva S, Santos LC, Ramos L, Silva E.   +6 more
europepmc   +2 more sources

Use of methadone as an alternative to morphine for chronic pain management: a noninferiority retrospective observational study

PAIN Reports, 2021
. Introduction:. Chronic pain causes disability and is prevalent in the general population. Opioids are a part of a multimodal strategy for pain management.
Guilherme Antonio Moreira de Barros, Ricardo Baradelli, Debora Garcia Rodrigues, Odaly Toffoletto, Flavia Seullner Domingues, Maisa Vitoria Gayoso, Alexandre Lopes, Jorge Barros Afiune, Gabriel Magalhães Nunes Guimarães   +8 more
doaj   +1 more source

In Vitro and Preclinical Antitumor Evaluation of Doxorubicin Liposomes Coated with a Cholesterol-Based Trimeric β-D-Glucopyranosyltriazole

Pharmaceutics, 2023
The coating of liposomes with polyethyleneglycol (PEG) has been extensively discussed over the years as a strategy for enhancing the in vivo and in vitro stability of nanostructures, including doxorubicin-loaded liposomes.
Aline Teixeira Maciel e Silva, Ana Luiza Chaves Maia, Juliana de Oliveira Silva, Sued Eustáquio Mendes Miranda, Talia Silva Cantini, Andre Luis Branco de Barros, Daniel Crístian Ferreira Soares, Mariana Torquato Quezado de Magalhães, Ricardo José Alves, Gilson Andrade Ramaldes   +9 more
doaj   +1 more source

Contaminação de medicamentos com nitrosaminas: riscos sanitários e ações de recolhimento de produtos no Brasil [PDF]

Infarma: Pharmaceutical Sciences, 2022
Nitrosaminas são compostos mutagênicos pertencentes ao grupo de preocupação, visto que apresentam elevado potencial carcinogênico. Desde 2018, impurezas do tipo nitrosamina foram detectadas em insumos farmacêuticos ativos e produtos farmacêuticos.
Juliana Yi Dan Wu, Jaqueline Kalleian Eseria, Márcia Lombardo   +2 more
doaj   +1 more source

Cardiovascular and respiratory evaluation in adenosine A2A receptor knockout mice submitted to short‐term sustained hypoxia

Experimental Physiology, Volume 108, Issue 11, Page 1434-1445, 1 November 2023., 2023
Abstract Sustained hypoxia (SH) in mice induces changes in the respiratory pattern and increase in the parasympathetic tone to the heart. Among adenosine G‐protein‐coupled receptors (GPCRs), the A2A receptors are especially important in mediating adenosine actions during hypoxia due to their expression in neurons involved with the generation and ...
Juliana R. Souza, Benedito H. Machado
wiley   +1 more source

Nanomedicine in Oncocardiology: Contribution and Perspectives of Preclinical Studies

Frontiers in Cardiovascular Medicine, 2021
Cancer and cardiovascular diseases are the leading causes of death and morbidity worldwide. Strikingly, cardiovascular disorders are more common and more severe in cancer patients than in the general population, increasing incidence rates.
Gabriel Silva Marques Borges, Gabriel Silva Marques Borges, Eduardo Burgarelli Lages, Eduardo Burgarelli Lages, Pierre Sicard, Pierre Sicard, Lucas Antônio Miranda Ferreira, Sylvain Richard, Sylvain Richard   +8 more
doaj   +1 more source

Efficacy and safety of brolucizumab in age‐related macular degeneration: A systematic review of real‐world studies

Acta Ophthalmologica, Volume 101, Issue 2, Page 123-139, March 2023., 2023
Abstract Intravitreally injected anti‐vascular endothelial growth factor (anti‐VEGF) agents are first‐line treatment for neovascular age‐related macular degeneration (nAMD). Phase 3 trials demonstrated non‐inferiority of anti‐VEGF therapy with brolucizumab compared with aflibercept in best corrected visual acuity (BCVA) gains, with superior anatomical ...
Caroline R. Baumal, Torben Lykke Sørensen, Helene Karcher, Rita L. Freitas, Anja Becher, Sébastien Balez, Andreas Clemens, Michael Singer, Laurent Kodjikian   +8 more
wiley   +1 more source

Short exposure to high salt in drinking solution leads to a cardiovascular phenotype of hypertension without changes in the blood volume of rats

Experimental Physiology, Volume 108, Issue 3, Page 361-370, 1 March 2023., 2023
Abstract Evidence suggests that hypertension induced by high salt intake is correlated with an autonomic imbalance that favours sympathetic hyperactivity and an increase in vascular resistance, indicating a neurogenic component to this pathology.
Paula Magalhães Gomes, Julia Santos Batista, Renato Willian Martins Sá, Vagner Roberto Antunes   +3 more
wiley   +1 more source

PB2510: CHARACTERISATION OF SICKLE CELL DISEASE PATIENTS: A PORTUGUESE REAL-WORLD STUDY (ASCEND) [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
Deveza M, Da Fonseca I, Monteiro Saunders C, Major M, Tome A, Martins J, Maia T, Bento C, Brás D.   +8 more
europepmc   +2 more sources

Comparative evaluation of the sedative and physiological effects of medetomidine alone and in combination with pethidine, morphine, tramadol, and methadone in goats

Veterinary Medicine and Science, Volume 8, Issue 4, Page 1664-1670, July 2022., 2022
Abstract Background The use of combinations of α2‐adrenergic agonists and opioids has been published as providing superior sedation than either drug alone. Introduction The present study aims to compare the sedative and physiological effects of intravenous (IV) administration of medetomidine alone and in combination with methadone, morphine, tramadol ...
Maryam Salarpour, Ehsanollah Sakhaee, Amir Saeed Samimi, Omid Azari   +3 more
wiley   +1 more source