Results 31 to 40 of about 34,036 (135)

Advances in the Search for SARS-CoV-2 Mpro and PLpro Inhibitors

open access: yesPathogens
SARS-CoV-2 is a spherical, positive-sense, single-stranded RNA virus with a large genome, responsible for encoding both structural proteins, vital for the viral particle’s architecture, and non-structural proteins, critical for the virus’s replication ...
Marcel Arruda Diogo   +2 more
doaj   +1 more source

Crystal structure of 4-nitrophenyl 6-O-ethyl-β-d-galactopyranoside monohydrate

open access: yesActa Crystallographica Section E: Crystallographic Communications, 2017
The synthesis and crystal structure of the title compound, C14H19NO8·H2O, prepared in three steps from 6-O-ethyl-1,2;3,4-di-O-isopropylidene-α-d-galactopyranose using protecting-group strategies employed in carbohydrate chemistry, is reported.
Bruno Leonardo Silva   +2 more
doaj   +1 more source

Regulação, circulação e distribuição da penicilina em Portugal (1944-1954) [PDF]

open access: yes, 2017
Portugal foi um dos primeiros países do mundo, não participantes na II Guerra Mundial, a obter penicilina para uso civil. Em 1944 o medicamento começou a ser importado dos Estados Unidos da América pela Cruz Vermelha Portuguesa, mas como as quantidades ...
Bell, Victoria   +2 more
core   +2 more sources

Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2‐Dependent Modulation of Subthreshold Currents

open access: yesJournal of Neurochemistry, Volume 170, Issue 1, January 2026.
General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo   +4 more
wiley   +1 more source

Relatório de estágio em farmácia hospitalar [PDF]

open access: yes, 2016
Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de ...
Alves, Joana Taquelim Marreiros
core   +3 more sources

Impacto das alterações na despesa em saúde nos indicadores de saúde: análise em painel [PDF]

open access: yes, 2014
A exigência de rigor orçamental obriga a uma racionalização de recursos e da despesa em saúde. Várias políticas públicas têm contribuindo para a redução e controlo desta despesa embora pouco se conheça o impacto de tal redução nos indicadores de saúde
Martins, Carla, Nunes, Alcina
core  

Histamine in Brazilian Foods: A Comprehensive Review of Occurrence and Risk Assessment for Intoxication and Intolerance

open access: yesFood Science &Nutrition, Volume 13, Issue 11, November 2025.
Even though histamine plays an important role in human health, it has been associated with food intoxication and intolerance episodes. The most relevant, current state of knowledge regarding histamine's biochemical and health aspects is provided. Histamine levels are provided for 17 food groups, including 335 food types and 11,437 samples, allowing ...
Maria Beatriz A. Gloria   +6 more
wiley   +1 more source

Green Strategies for the Synthesis of Heterocyclic Derivatives with Potential Against Neglected Tropical Diseases

open access: yesReactions
Neglected tropical diseases (NTDs) remain a significant global health burden, exacerbated by the ongoing climate emergency, which alters disease distribution and increases vulnerability in affected populations.
Vinícius Augusto Campos Péret   +1 more
doaj   +1 more source

Farmácia e medicamentos em Portugal em meados do século XX. O papel da Comissão Reguladora dos Produtos Químicos e Farmacêuticos (1940) [PDF]

open access: yes, 2014
A primeira metade do século XX caracteriza-se pelo processo intenso de industrialização do medicamento e pelo aparecimento de novos grupos terapêuticos medicamentosos.Neste trabalho os autores dão a conhecer resultados da investigação em curso sobre o ...
Pereira, Ana Leonor   +2 more
core   +1 more source

Body and Testicular Biometry and Epididymal Sperm Characteristics in Sambar Deer (Rusa unicolor (Kerr, 1792))

open access: yesReproduction in Domestic Animals, Volume 60, Issue 9, September 2025.
ABSTRACT Characterising body and reproductive morphometry and their association with epididymal sperm quality can contribute to the conservation of sambar deer (Rusa unicolor). Five adult males maintained in captivity at the Getúlio Vargas Zoobotanical Park (Salvador, BA, Brazil) were captured, anaesthetised, and subjected to bilateral orchiectomy as ...
Isabella de Matos Brandão Carneiro   +9 more
wiley   +1 more source

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