Results 11 to 20 of about 431,675 (178)

Cardiovascular and respiratory evaluation in adenosine A2A receptor knockout mice submitted to short‐term sustained hypoxia

Experimental Physiology, Volume 108, Issue 11, Page 1434-1445, 1 November 2023., 2023
Abstract Sustained hypoxia (SH) in mice induces changes in the respiratory pattern and increase in the parasympathetic tone to the heart. Among adenosine G‐protein‐coupled receptors (GPCRs), the A2A receptors are especially important in mediating adenosine actions during hypoxia due to their expression in neurons involved with the generation and ...
Juliana R. Souza, Benedito H. Machado
wiley   +1 more source

Pseudomonas aeruginosa isolation from dog grooming products used by private owners or by professional pet grooming salons: prevalence and risk factors

Veterinary Dermatology, Volume 33, Issue 4, Page 316-e73, August 2022., 2022
Abstract Background Pseudomonas aeruginosa is the most commonly isolated bacterium from skin lesions of dogs with post‐grooming furunculosis (PGF). It is frequently found in human hair and skin care products, and may pose a health risk to consumers. Information regarding the prevalence of P. aeruginosa contamination of dog grooming products is lacking.
Elad Perry, Gila Abells Sutton, Lotem Haggag, Marcelo Fleker, Shlomo Eduardo Blum, Ronnie Kaufmann   +5 more
wiley   +1 more source

Lacunas e falhas relacionadas à importação de produtos para a saúde em contêiner

Vigilância Sanitária em Debate, 2016
Metade das mercadorias relacionadas à saúde, importadas via Porto do Rio de Janeiro, é armazenada em contêineres, 70% deles não possui sistema de refrigeração, por isto, não é possível assegurar a manutenção das recomendações do fabricante conforme exigem as regulamentações sanitárias estabelecidas.
Mariene Castilho D'Ãvila, Patrícia Fernandes S. Nobre, Kátia Christina Leandro   +2 more
openaire   +5 more sources

When innovation outpaces regulations: The legal challenges for direct‐to‐patient supply of investigational medicinal products

British Journal of Clinical Pharmacology, Volume 88, Issue 3, Page 1115-1142, March 2022., 2022
Aims We profile the lack of specific regulation for direct‐to‐patient postal supply (DTP) of clinical trial medications (investigational medicinal products, IMPs) calling for increased efficiency of patient‐centred multi‐country remote clinical trials.
Maeve Malone, Pamela Ferguson, Amy Rogers, Isla S. Mackenzie, David A. Rorie, Thomas M. MacDonald   +5 more
wiley   +1 more source

Evaluation of Toxicity and Oxidative Stress of 2‐Acetylpyridine‐N(4)‐orthochlorophenyl Thiosemicarbazone

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Thiosemicarbazones are well known for their broad spectrum of action, including antitumoral and antiparasitic activities. Thiosemicarbazones work as chelating binders, reacting with metal ions. The objective of this work was to investigate the in silico, in vitro, and in vivo toxicity and oxidative stress of 2‐acetylpyridine‐N(4)‐orthochlorophenyl ...
Andressa Brito Lira, Gabrieli Lessa Parrilha, Gabriela Tafaela Dias, Fernanda Samara de Sousa Saraiva, Gabriel Corrêa Veríssimo, Rayane Siqueira de Sousa, Teresinha Gonçalves da Silva, Abrahão Alves de Oliveira Filho, Adriano Francisco Alves, Elaine Maria de Souza-Fagundes, Heloisa Beraldo, Maria Aparecida Gomes, Margareth de Fatima Formiga Melo Diniz, Junmin Zhang   +13 more
wiley   +1 more source

Flavonols and Flavones as Potential anti‐Inflammatory, Antioxidant, and Antibacterial Compounds

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Plant preparations have been used to treat various diseases and discussed for centuries. Research has advanced to discover and identify the plant components with beneficial effects and reveal their underlying mechanisms. Flavonoids are phytoconstituents with anti‐inflammatory, antimutagenic, anticarcinogenic, and antimicrobial properties.
Maria do Socorro S. Chagas, Maria D. Behrens, Carla J. Moragas-Tellis, Gabriela X. M. Penedo, Adriana R. Silva, Cassiano F. Gonçalves-de-Albuquerque, Cristina Angeloni   +6 more
wiley   +1 more source

Análise do impacto da avaliação clínica no registro sanitário de dispositivos médicos de alto risco

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2019
Introdução: A avaliação clínica de dispositivos médicos é um componente importante na avaliação de novas tecnologias para fins de registro sanitário no âmbito da Agência Nacional de Vigilância Sanitária e representa uma ferramenta importante para a ...
Alessandro Ferreira do Nascimento
doaj   +1 more source

Perfil do registro sanitário de dispositivos intersomáticos na Agência Nacional De Vigilância Sanitária (Anvisa) [PDF]

Infarma: Pharmaceutical Sciences, 2019
Produtos para saúde são dispositivos de uso médico utilizados em variados procedimentos e estão sujeitos à vigilância sanitária. A comercialização, no Brasil, requer o registro na Agência Nacional de Vigilância Sanitária (Anvisa), que avalia o grau de ...
Luciana Ferreira Mattos COLLI, Anna Luisa Dantas MARTINS, Lucio Mendes CABRAL   +2 more
doaj   +1 more source

Intercambialidade de produtos biológicos no Sistema Único de Saúde (SUS): principais desafios regulatórios [PDF]

Cadernos de Saúde Pública, 2019
Resumo: Produtos biológicos revolucionaram a terapêutica mundial. O alto custo desses medicamentos, no entanto, ameaça a sustentabilidade dos sistemas de saúde.
Paula Teixeira Pinto Ferreira Neto, Patrícia Helena Castro Nunes, Marco Antonio Vargas   +2 more
doaj   +1 more source

Radiometric Survey in Mammography: Review of regulations, recommendations, field and laboratories practices and first tests.

Brazilian Journal of Radiation Sciences, 2019
A review about Radiometric Survey in Mammography (RSM) in terms of regulatory documents, recommendations, radiation meters, besides field and laboratories practices shows that there is not many specific information about how these radiation area ...
Eric Matos Macedo, Marcus Vinicius Teixeira Navarro, Daniele Andrade Jesus, Igor Fernando Modesto Garcia, Handerson Jorge Dourado Leite, José Guilherme Pereira Peixoto   +5 more
doaj   +1 more source