Results 251 to 260 of about 1,605,420 (342)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?

open access: yesAdvanced Science, EarlyView.
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen   +5 more
wiley   +1 more source

Heading in football matches: descriptive analysis of heading events from 687 matches across age groups in English Academy and First Team men's professional football. [PDF]

open access: yesBr J Sports Med
Brownlow M   +11 more
europepmc   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

open access: yesAdvanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng   +11 more
wiley   +1 more source

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