This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
The impact of physical exercise on primary school teachers' professional ethics: the mediating role of self-control. [PDF]
Kequn C, Xiuqing Y, Tinghui Z.
europepmc +1 more source
How AI Shapes the Future Landscape of Sustainable Building Design With Climate Change Challenges?
This review examines how artificial intelligence reshapes sustainable building design faced with climate change challenges. The authors synthesize existing studies to demonstrate AI's transformative potential across design lifecycle phases from climate‐aware form generation to performance optimization.
Pengyuan Shen +5 more
wiley +1 more source
Taking a moral holiday? Physicians' practical identities at the margins of professional ethics. [PDF]
van Gils-Schmidt HJ, Salloch S.
europepmc +1 more source
Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng +11 more
wiley +1 more source
Key components in the professional ethics of sign language interpreters in healthcare contexts: a qualitative study in Colombia. [PDF]
Izquierdo Martínez LC +5 more
europepmc +1 more source
Designing a model of professional ethics excellence for clinical librarians. [PDF]
Ashrafi-Rizi H +3 more
europepmc +1 more source
Human Skin‐Inspired Flexible Pressure Sensor with Multi‐Modulus Porous Structure
Skin‐inspired dual‐modulus pressure sensor is developed by mimicking epidermis–dermis mechanics with a porous MWCNT/PDMS composite, achieving high sensitivity and wide linear range through simple fabrication, and enabling scalable, cost‐effective applications in wearable electronics, robotics, and human–machine interfaces.
Hyeongmin Park +12 more
wiley +1 more source
Inhibitors and facilitators of compliance with professional ethics standards: nurses' perspective. [PDF]
Sharifi S +5 more
europepmc +1 more source

