Results 181 to 190 of about 3,938,088 (371)

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

open access: yesAdvanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin   +7 more
wiley   +1 more source

A blended-learning programme regarding professional ethics in physiotherapy students

open access: yesNursing Ethics, 2019
M. Aguilar-Rodríguez   +5 more
semanticscholar   +1 more source

Born to Fear the Machine? Genetic and Environmental Influences on Negative Attitudes toward AI Agents

open access: yesAdvanced Science, EarlyView.
Why do some people fear or distrust AI agents more than others? This twin study shows that negative attitudes toward AI may partly stem from genetic factors, linking them to traits like victim sensitivity and moral beliefs. These findings show that it is not only nurture but also nature that shapes our views of AI, with implications for future human–AI
Xiaojiayu Tan   +7 more
wiley   +1 more source

Spatiotemporal Adaptations‐Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response

open access: yesAdvanced Science, EarlyView.
This study uncovers the thyroid hormone receptor Thra as a pivotal regulator that spatiotemporally orchestrates dual‐phase skin repair. Epidermal Thra accelerates barrier restoration via glutathione‐driven keratin assembly, while dermal Thra establishes angiogenic niches through SAA3‐FN1‐mediated matrix remodeling.
Zeming Li   +15 more
wiley   +1 more source

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