This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
Bridging the gap: evaluation of the impact of a structured pre-professional medical education gap year on medical career pathway, competency development, and preparedness for professional school. [PDF]
Regester RM +5 more
europepmc +1 more source
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed +10 more
wiley +1 more source
A qualitative evaluation of a global surgery course within the University of Cape Town's master of public health curriculum: A cross-sectional study. [PDF]
Zolo Y +5 more
europepmc +1 more source
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo +9 more
wiley +1 more source
Strengthening initial teacher education programs to deliver confident, effective, classroom-ready graduates: a feasibility study. [PDF]
Riley N +4 more
europepmc +1 more source
Master Of Engineering Program As A Mechanism To Provide Relevant Graduate Education To Working Professionals [PDF]
Eugene Rutz, Timothy C. Keener
openalex +1 more source
Business education. The professional master program: seeking its own identity
This paper intends to identify and analyze important issues in the discussion about the Executive Master Programs (Mestrado Modalidade Profissional, MPA) in Brazil. Starting with a general view about the requirements that motivate the executive development programs more important in Brazil (Lato Sensu Postgraduate or Certificate Level ...
openaire +1 more source
Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini +8 more
wiley +1 more source

