Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Evaluating professional performance of environmental educators
Transformación, 2013 The paper is intended to outline criteria for evaluating professional performance of environmental educators by describing dimensions, sub-dimensions and indicators for appraising the professional performance of environmental educators’ variable ...
Loret de Mola, E. +2 more
doaj
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Supporting professional identity in novice practitioners through reflective practice
, 2011 This study investigates how full-time students on the Foundation degree (FdA) in Early Years develop a professional identity as early years practitioners, including how they conceptualise and judge good practice and how they evaluate and reflect on their
Taylor, Susan M., Dyer, Mary A.
core
Nurses' Professional Performance: The Development and Evaluation of a Formative Workplace-Based Self-Assessment Instrument. [PDF]
Int J Nurs Stud AdvVasse FMD +3 more
europepmc +1 more source
Advanced Science, EarlyView.A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang +11 more
wiley +1 more source
Accounting and the ethics challenge: Re-membering the professional body
Based on the P.D. Leake Lecture given at Chartered Accountants’ Hall in May 2007, this paper looks beyond recent financial reporting ‘scandals’ to consider the ‘standing challenge’ that ethics represents for accountants and the professional bodies ...
Cowton, Christopher J.
core
Assessment of simulated participant professional performance in health professional education: a scoping review. [PDF]
Adv Simul (Lond)León-Ariza SA +4 more
europepmc +1 more source
Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays
Advanced Science, EarlyView.ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen +13 more
wiley +1 more source
Transforming pharmacy practice through contemporary leadership models: Behaviouraldrivers of workplace motivation, innovation and professional performance. [PDF]
Explor Res Clin Soc PharmAlqarni YS.
europepmc +1 more source