Results 171 to 180 of about 693,267 (263)

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Audit and feedback: effects on professional practice. [PDF]

Cochrane Database Syst Rev
Ivers N, Yogasingam S, Lacroix M, Brown KA, Antony J, Soobiah C, Simeoni M, Willis TA, Crawshaw J, Antonopoulou V, Meyer C, Solbak NM, Murray BJ, Butler EA, Lepage S, Giltenane M, Carter MD, Fontaine G, Sykes M, Halasy M, Bazazo A, Seaton S, Canavan T, Alderson S, Reis C, Linklater S, Lalor A, Fletcher A, Gearon E, Jenkins H, Wallis JA, Grobler L, Beccaria L, Cyril S, Rozbroj T, Han JX, Xu AX, Wu K, Rouleau G, Shah M, Konnyu K, Colquhoun H, Presseau J, O'Connor D, Lorencatto F, Grimshaw JM.   +45 more
europepmc   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Improving maternity and neonatal care in England: protocol for a formative evaluation of the implementation of the core competency framework to enhance multi-professional practice. [PDF]

BMC Pregnancy Childbirth
Whybrow R, Robert G, Dagustun J, Ahuja S, Brown H, Bassett S, Parr M, Adeyinka T, Glenday S, Cross S, Sharma E, Zoccatelli G.   +11 more
europepmc   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Nurses' perception of the professional practice environment and its relation to organizational dehumanization and work passion. [PDF]

BMC Nurs
Salem SM, Bakeer HM, El Shrief HA.
europepmc   +1 more source

An Epidermal Sweat Patch for Tracking Metabolite Levels and Correlation Analysis in Biofluids

Advanced Science, EarlyView.
This work presents an epidermal sweat patch for continuous glucose monitoring that validates a strong correlation between sweat, interstitial fluid and blood, enabling a reliable and non‐invasive platform for systemic health management. ABSTRACT Continuous, in situ monitoring of sweat biomarkers offers a promising approach for non‐invasive metabolic ...
Yao Chen, Xinhao Wan, Haoxin Fan, Hengwei Lou, Jialu Wang, Jie Gao, Dan Wen   +6 more
wiley   +1 more source

Focused Professional Practice Evaluation and the Weaponization of Anonymous Reporting: Erosion of Care and Fairness. [PDF]

Cureus
Moore D, Zhan J, Matlack R, Zaki M, Samadani U, Abbasi H.   +5 more
europepmc   +1 more source