Results 131 to 140 of about 4,308 (188)

Hubris in the age of intelligent medicine-from clinical hierarchies to algorithmic amplification. [PDF]

NPJ Digit Med
Patel MS, Scales D, Arslan J, Pedrelli P, Crowson MG, Abulibdeh R, Celi LA.   +6 more
europepmc   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Endometrial Cancer by ERBB2 Amplification (ERBB2amp) Status: Differences in Molecular Subtypes, Ancestry, and Real-World Outcomes. [PDF]

JCO Precis Oncol
Cantillo E, Podder V, Danziger N, Lobo D, Lin DI, Graf RP, Coleman RL, Pothuri B, Eskander RN, Herzog TJ, Slomovitz BM.   +10 more
europepmc   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Approach to Diagnosis and Management of Polycystic Ovary Syndrome in Bangladesh: A Nationwide Cross-Sectional Survey of Physicians. [PDF]

Cureus
Mustari M, Raunak AIB, Mahjabeen S, Mahmood SA, Afsana F, Saifuddin M, Haq T, Islam S, Hossain T, Mohiuddin SM, Akter N, Ahammed A, Sobhan R, Rahman S, Sarkar S, Pathan MF, Rahman MH, Tanni AZ, Selim S.   +18 more
europepmc   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Molecular tumor board availability and organization in sarcoma referral centers in Italy: are we on the right track? [PDF]

Front Oncol
Onesti CE, Casini B, De Chiara A, Fausti V, Luksch R, Milano GM, Palmerini E, Vari S, Ceddia S, Riva F, Ibrahim T, Covello R, Ciliberto G, Scotlandi K, Ferraresi V.   +14 more
europepmc   +1 more source

Protonation Modification of Commercial OPBI as Binders Toward High‐Performance High‐Temperature PEM Fuel Cells

Advanced Science, EarlyView.
Commercial OPBI binders is regulated via a facile formic‐acid protonation strategy without disrupting the polymer backbone. Protonation introduces positively charged benzimidazole sites, inducing interchain electrostatic repulsion that loosens chain packing, enlarges intermolecular spacing, and promotes uniform binder dispersion over catalyst surfaces.
Jinzhen Huang, Minhui Liang, Jingjing Lin, Zhihuan Pan, Jinwu Peng, Lei Wang   +5 more
wiley   +1 more source

Assessment of simulated participant professional performance in health professional education: a scoping review. [PDF]

Adv Simul (Lond)
León-Ariza SA, Ríos-Villarreal EF, Yepes-Núñez J, Castaño-Duque S, Jaramillo-Rincón SX.   +4 more
europepmc   +1 more source

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source