Results 181 to 190 of about 413,951 (302)

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

The Impact of Self-Compassion on Enhancing the Professional Quality of Life for Healthcare Workers. [PDF]

J Korean Med Sci
Jung E, Jung YE.
europepmc   +1 more source

Quality of Life Assessment of the Wandering Emergency Service Care professionals

, 2016
Cristiane da Silva Ramos Marinho, Juliana Martins de Menezes, Cecília Nogueira Valença, Ilisdayne Thallita Soares da Silva, Mayonara Fabíola Silva Araújo, Luíz Alves Morais Filho, Osvaldo de Góes Bay, Quênia Camille Soares Martins, Maria Leonor Paiva da Silva, Rafaela Carolini de Oliveira Távora, Mayara Silva Fernandes do Rêgo, Renata Fonsêca Sousa de Oliveira, Fábia Cheyenne Gomes de Morais Fernandes   +12 more
openalex   +2 more sources

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

Advanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang, Yangfan Ye, Wei Gu, Xinyue Wang, Nuo Chen, Qixin He, Lei Xu, Pengzhan Zhao, Guoqiang Fu, Guangyao Yuan, Wenqian Shi, Honglu Chao, Yiming Tu, Jing Ji   +13 more
wiley   +1 more source

The Effect of Team Job Crafting on Professional Quality of Life Among Nurses: A Latent Profile Analysis. [PDF]

J Nurs Manag
Zhou XH, Duan DF, Chen L, Zhang YJ, Gong S, Chen Q.   +5 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Understanding the link between mental health disorders and professional quality of life among humanitarian workers: A cross-sectional study from the Thai-Myanmar border. [PDF]

Public Health Pract (Oxf)
Mahato RK, Paw NL, Htike KM, Nawawonganun R.   +3 more
europepmc   +1 more source

PROFESSIONAL QUALITY OF LIFE AND FACTORS ASSOCIATED IN HEALTH PROFESSIONALS

Psicologia, Saúde & Doença, 2019
Jaqueline Torres, Henrique Barbosa, Sabrina Pereira, Franciele Cunha, Silvério Torres, Maria Brito, Lucinéia Pinho, Danilo Mendes, Carla Silva   +8 more
openaire   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source