Results 91 to 100 of about 744,615 (290)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Defining proficiency

open access: yesDutch Journal of Applied Linguistics, 2013
In this study, various proficiency classification methods are explored in order to describe the relevant levels on the Common European Framework of Reference for Languages (CEF) that are represented by a group of 127 incoming English students at a Dutch university with respect to academic writing.
Rebecca L. Present-Thomas   +2 more
openaire   +1 more source

Short-Term Study Abroad: Perspectives on Speaking Gains and Language Contact [PDF]

open access: yes, 2016
Previous studies have shown that study abroad has a positive effect on second language (L2) learning outcomes for students who spend at least a semester abroad.
Hernandez, Todd A
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Typical Elements in Limited English Proficiency Plans [PDF]

open access: yes, 2015
EqualityCivilRights__Key_Elements_for_an_LEP_Plan.pdf: 15 downloads, before Oct.
Mizell, Melinda
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Bestimmung des Sprachstands in einer Herkunftssprache: Ein Vergleich verschiedener Testverfahren am Beispiel des Polnischen als Herkunftssprache in Deutschland. Determining proficiency in a heritage language: A comparison of different testing methods based on Polish as a heritage language in Germany

open access: yesGlottodidactica, 2016
The paper discusses several methods of evaluating heritage speakers’ abilities in their heritage language. Speech rate in spontaneous text production, lexical knowledge and grammatical proficiency in the heritage language have been found to correlate ...
Bernhard Brehmer
doaj   +1 more source

Achieving Equity by Building a Bridge From Eligible to Enrolled [PDF]

open access: yes, 2012
Calls for multilingual outreach and enrollment efforts to enable Californians of color and those with limited English proficiency to benefit from the Health Benefit Exchange.
Christina M. Kinane   +9 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Intra-laboratory quality control for chicken raw materials - doi: 10.4025/actascitechnol.v35i3.12657

open access: yesActa Scientiarum: Technology, 2013
In recent times, food and water laboratories have aimed to improve their processes to meet market demands. In order to contribute to the efficacy and development of these processes, new methods must be sought, among which is intra-laboratory quality ...
Elizabeth Giron   +1 more
doaj   +1 more source

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