Results 161 to 170 of about 153,236 (267)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Quality Improvement in Residency: Training, Projects, and Outcomes. [PDF]

Ann Fam Med
Harriett LE, Wright KM, Anderson L, Wheat S, Harrison L, Rowland K, Oshman L, Worringer E, Prunuske J.   +8 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development and validation of objective performance metrics for robot-assisted basic surgical skills in a simulated anastomosis task using a single-port robotic system. [PDF]

J Robot Surg
Beatrici E, Santarelli V, Guidotti A, Pepillo F, de Angelis M, Barretta A, Cei F, Frego N, Paciotti M, Vanderstraeten E, Van Herzeele I, Puliatti S, De Naeyer G, Farinha R, De Groote R, Hemal S, Wiklund P, Crivellaro S, Challacombe B, Rashidian N, Mottrie A.   +20 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

AI-enhanced social media affordances and intercultural communication competence: engagement, identity integration, and English proficiency. [PDF]

Front Psychol
Ma R.
europepmc   +1 more source

English Proficiency/Fluent English Proficient Students

, 2013
openaire   +2 more sources