Results 81 to 90 of about 744,615 (290)

Many Californians With Asthma Have Problems Understanding Their Doctor [PDF]

open access: yes, 2009
Examines the prevalence and consequences of communication problems with doctors among adult asthma patients by education, income, insurance status, English proficiency, race/ethnicity, and nativity.
Malia Jones   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Using Preschool to Close the Socioeconomic Math Achievement Gap [PDF]

open access: yes, 2020
Socioeconomic status (SES) heavily influences students’ academic performance, creating an achievement gap in core subjects like reading and mathematics. This thesis will describe the socioeconomic achievement gap as it relates to mathematics specifically,
King, Sydney
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Affordable Language Services: Implications for Health Care Organizations [PDF]

open access: yes, 2007
Outlines the need to provide medical interpreters and healthcare material for patients with limited English proficiency. Summarizes RWJF's Hablamos Juntos initiative to develop affordable ways to remove language barriers and discusses lessons ...

core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The SLS-Berlin: Validation of a German Computer-Based Screening Test to Measure Reading Proficiency in Early and Late Adulthood [PDF]

open access: yes, 2019
Reading proficiency, i.e., successfully integrating early word-based information and utilizing this information in later processes of sentence and text comprehension, and its assessment is subject to extensive research.
Froehlich, Eva   +3 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Lessons for PreK-3rd From Montgomery County Public Schools [PDF]

open access: yes, 2010
Presents a case study of how a district improved third-grade reading proficiency rates and narrowed the achievement gap, in spite of growing English Language Learner and low-income populations, by implementing an integrated early learning ...
Geoff Marietta
core  

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