Results 201 to 210 of about 324,234 (331)

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Novel Approach to Proficiency Testing Reveals Significant Variations in Biomarker Practice Leading to Critical Differences in Lung Cancer Management. [PDF]

JTO Clin Res Rep
Bisson KR, Beharry A, Blais N, Carter MD, Cheema PK, Desmeules P, Garratt JG, Melosky B, Lo B, Snow S, Tessier-Cloutier B, Tio E, Yip S, Won JR, Sheffield BS.   +14 more
europepmc   +1 more source

Proficiency testing of PIK3CA mutations in HR+/HER2-breast cancer on liquid biopsy and tissue. [PDF]

Virchows Arch, 2023
Vollbrecht C, Hoffmann I, Lehmann A, Merkelbach-Bruse S, Fassunke J, Wagener-Ryczek S, Ball M, Dimitrova L, Hartmann A, Stöhr R, Erber R, Weichert W, Pfarr N, Bohlmann L, Jung A, Dietmaier W, Dietel M, Horst D, Hummel M.   +18 more
europepmc   +1 more source

Testing for Communicative Proficiency: A Scenario-Based Approach

, 1995
Jane Davics
openalex   +2 more sources

High proficiency in detecting the six major hepatitis C virus genotypes of laboratories involved in testing plasma by nucleic acid amplification technology [PDF]

, 2003
G. Gentili, Giulio Pisani, J. Saldanha, Karen Cristiano, Maria Wirz, Guillermo M. Bisso, Claudio Mele   +6 more
openalex   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Evaluating the Effectiveness of External Molecular Proficiency Testing in the Global Polio Laboratory Network, 2021-2022. [PDF]

Pathogens
Gerloff N, Burns CC.
europepmc   +1 more source

Challenges in Drug Surveillance: Strengthening the Analysis of New Psychoactive Substances by Harmonizing Drug Checking Services in Proficiency Testing. [PDF]

Int J Environ Res Public Health, 2023
Balcaen M, Ventura M, Gil C, Luf A, Martins D, Cunha M, Tögel-Lins K, Wolf D, Blanckaert P, Deconinck E.   +9 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Determining Moisture Content in Milk Powder: Challenges in the Evaluation of Performance by Proficiency Testing Using Independent Reference Values. [PDF]

Sensors (Basel)
Poo S, Palma M, Muñoz O.
europepmc   +1 more source