Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
A reliable quantification of organophosphorus pesticides in brown rice samples for proficiency testing using Japanese official analytical method, QuEChERS, and modified QuEChERS combined with isotope dilution mass spectrometry. [PDF]
Otake T +3 more
europepmc +1 more source
Low utilization of epidemiological cutoff values to interpret <i>in vitro</i> antifungal susceptibility testing among clinical laboratory participants in two College of American Pathologists (CAP) proficiency testing programs. [PDF]
Sullivan KV +5 more
europepmc +1 more source
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Proficiency testing in agriculture
Veterinary Record, 1977The development and organisation of proficiency testing in agriculture in England and Wales is described. The National Proficiency Tests Council, which was established as an independent examining body in 1971, is responsible for administering the proficiency testing scheme at a national level.
M, Hinton, P C, Sheppy
openaire +2 more sources
Proficiency testing of sampling
Analytical Methods, 2017Proficiency testing of analytical laboratories is now ubiquitous-laboratories need to participate regularly to receive accreditation. The outcome helps participants to detect unexpected sources of uncertainty. But sampling, as well as analysis per se, introduces its own uncertainty in most types of analysis.
openaire +2 more sources
Proficiency testing of radioimmunoassay
Clinical Biochemistry, 19761. Quality control is essential during the setting up and routine application of radioimmunoassay. 2. Aspects discussed include the 50% binding intercept, slope of standard curve, and inter- and intra-assay variance.
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Proficiency of Office Microbiology Testing
Clinics in Laboratory Medicine, 1986Microbiology proficiency testing results from smaller physicians' office laboratories in the state of Pennsylvania are reviewed. Possible reasons for lower performance levels are discussed, and some approaches to improving microbiology proficiency in this setting are suggested.
R, Belsey, D M, Baer
openaire +2 more sources
Drug Abuse Proficiency Testing
Clinical Toxicology, 1977Concerning drugs in general, proficiency testing has undoubtedly been a major contributing factor to improved detection. Some of the improvement may be due to advances in technology, and this is possibly the case with improvement in the detection of morphine and methadone.
G O, Guerrant, C T, Hall
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A system for proficiency testing in immunohaematology
Clinical & Laboratory Haematology, 1981A compulsory programme of proficiency testing in immunohaematology has been conducted for the last 4 years. The collection, processing and analysis of testing data reported by participating laboratories depends on a computer-based system, which allows the generation of reports for participants and working documents essential to the functioning of a ...
S C, Ezer +6 more
openaire +2 more sources

