Results 61 to 70 of about 59,390 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Design, Implementation, and Evaluation of Proficiency Testing in EMC Burst Immunity

IEEE Access
For the accreditation according ISO/IEC 17025, the participation in the interlaboratory comparisons and proficiency testing is required as long as there exist suitable reference devices and providers.
Emrah Tas
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Introducing a Method for Achieving Standardization and Harmonization in Clinical and Research Laboratory Centers

Medical Laboratory Journal, 2014
Background and Objective: Proficiency testing schemes as a part of quality system in clinical and research laboratory centers provides the opportunity to evaluate the quality of test results.
M Dastmardi, A Ebrahimi, AZ Mirdamadi, A Ebrahimi, H Ebrahimi, SH Ebrahimzadeh Rajaee   +5 more
doaj  

Evaluation of Fecal Immunochemical Tests for Colorectal Cancer Screening

Journal of Primary Care & Community Health, 2013
Background: Colorectal cancer (CRC) screening reduces the mortality due to CRC. It is important for health care providers to be aware of the variation in the products available for CRC screening.
Jeanette M. Daly, Camden P. Bay, Barcey T. Levy   +2 more
doaj   +1 more source

Diagnostic use of proficiency testing in dairy laboratory

Acta Agriculturae Slovenica, 2004
The composition of raw milk (RM) is important for milk recording, herd improvement, payment of milk and for quality evaluation. The reliability of routine analytical results is therefore significant.
Oto HANUŠ, Václava GENČUROVÁ, Pavel HERING, Miloš KLIMEŠ, Radoslava JEDELSKÁ   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Implementing Blind Proficiency Testing

Forensic Science International: Synergy, 2023
Michael Salyards
doaj   +1 more source