Results 71 to 80 of about 2,914,956 (301)
Maximum likelihood parameter estimates and 95% profile confidence intervals.
, 2019 Maximum likelihood parameter estimates and 95% profile confidence intervals.
Rebecca Bridge (8156520) +5 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
SCYNet: testing supersymmetric models at the LHC with neural networks
European Physical Journal C: Particles and Fields, 2017 SCYNet (SUSY Calculating Yield Net) is a tool for testing supersymmetric models against LHC data. It uses neural network regression for a fast evaluation of the profile likelihood ratio.
Philip Bechtle +8 more
doaj +1 more source
, 2013 The grey line shows the log profile likelihood for R when selection is assumed to be uniform spatially (GNS = GEW = 0). The MLE of R in this case is 2.77 × 105 with a log-likelihood of −263.0.
Montgomery Slatkin (11467) +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Empirical Likelihood for Partial Parameters in ARMA Models with Infinite Variance
Journal of Applied Mathematics, 2014 This paper proposes a profile empirical likelihood for the partial parameters in ARMA(p,q) models with infinite variance. We introduce a smoothed empirical log-likelihood ratio statistic. Also, the paper proves a nonparametric version of Wilks’s theorem.
Jinyu Li, Wei Liang, Shuyuan He
doaj +1 more source
Profiles of depressive symptoms and influential factors among people living with HIV in China
BMC Public Health, 2023 Background Depressive symptoms are highly prevalent among people living with HIV (PLWH). We leveraged Latent Profile Analysis (LPA) to identify profiles of depressive symptoms among PLWHs.
Dongfang Wang +6 more
doaj +1 more source
A Note on the Calculation of Adjusted Profile Likelihood
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1993 SUMMARY An adjustment to the profile likelihood examined by Cox and Reid required orthogonalization of the nuisance parameters with respect to the parameter of interest. An approximation to the adjusted profile likelihood not requiring explicit orthogonalization is derived and exemplified.
Cox, D. R., Reid, N.
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source