Results 71 to 80 of about 327,047 (257)
A Note on the Calculation of Adjusted Profile Likelihood
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1993 SUMMARY An adjustment to the profile likelihood examined by Cox and Reid required orthogonalization of the nuisance parameters with respect to the parameter of interest. An approximation to the adjusted profile likelihood not requiring explicit orthogonalization is derived and exemplified.
Cox, D. R., Reid, N.
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in PsychologyObjectiveThis study aimed to use latent profile analysis (LPA) to identify heterogeneous configurational patterns of short video addiction and emotion dysregulation among college students, and to systematically examine the predictive effects of cognitive
Shuhe Wang, Zhongguo Liu
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A Nonparametric Bayesian Approach to the Rare Type Match Problem
Entropy, 2020 The “rare type match problem” is the situation in which, in a criminal case, the suspect’s DNA profile, matching the DNA profile of the crime stain, is not in the database of reference.
Giulia Cereda, Richard D. Gill
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A Profile Likelihood Approach for Longitudinal Data Analysis
Biometrics, 2017 SummaryInappropriate choice of working correlation structure in generalized estimating equations (GEE) could lead to inefficient parameter estimation while impractical normality assumption in likelihood approach would limit its applicability in longitudinal data analysis. In this article, we propose a profile likelihood method for estimating parameters
Ziqi Chen, Man-Lai Tang, Wei Gao
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Instance Based Approximations to Profile Maximum Likelihood
CoRR, 2020 Accepted at Thirty-fourth Conference on Neural Information Processing Systems (NeurIPS 2020)
Nima Anari +3 more
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