Results 161 to 170 of about 2,698,368 (301)
The directed modified profile likelihood in models with many nuisance parameters
, 1999 The modified profile likelihood is a higher-order approximation to a conditional or a marginal likelihood, when either exists. The directed likelihood based on the modified profile likelihood is standard normal only to first order. In practice, however,
PACE, Luigi +10 more
core
A note on profile likelihood for exponential tilt mixture models
Suppose that independent observations are drawn from multiple distributions, each of which is a mixture of two component distributions such that their log density ratio satisfies a linear model with a slope parameter and an intercept parameter. Inference
Z. Tan
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
In this paper, the only assumptions on the distribution of data are those concerning first two moments. Our purpose is to estimate the parameter of interest in the presence of nuisance parameter under these weak assumptions on the distribution. We define
Zhang, Runchu, Lin, Lu
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Profile Likelihoods on ML-Steroids
Profile likelihoods, for instance, describing global SMEFT analyses at the LHC are numerically expensive to construct and evaluate. Especially profiled likelihoods are notoriously unstable and noisy. We show how modern numerical tools, similar to neural importance sampling, lead to a huge numerical improvement and allow us to evaluate the complete ...
Heimel, Theo +2 more
openaire +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Profile Likelihood Method in Animal Breeding
, 2002 Varyans unsurları ve bunların fonksiyonlarına hayvan ıslahı uygulamalarında doğrudan ilgi duyulur. Bundan dolayı, bunlar hakkında yorumlamalar yapabilmek önem arzetmektedir.
Fırat, Mehmet Ziya
core
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source