Results 101 to 110 of about 2,583,946 (296)

Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems

open access: yesData in Brief, 2019
In the paper, “Probabilistic approaches to interpreting two-person DNA mixtures from post-coital specimens” [1], we analysed 102 two-person DNA samples from simulated mixtures and male-female and male-male post-coital specimens.
Jae Joseph Russell B. Rodriguez   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton-proton collisions at s=13TeV. [PDF]

open access: yesEur Phys J C Part Fields, 2023
Tumasyan A   +2351 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Constraint on Lorentz invariance violation for spectral lag transition in GRB 160625B using profile likelihood

open access: yesEuropean Physical Journal C: Particles and Fields
We reanalyze the spectral lag data for GRB 160625B using frequentist inference in order to constrain the energy scale $$(E_{QG})$$ ( E QG ) of Lorentz Invariance Violation (LIV).
Shantanu Desai, Shalini Ganguly
doaj   +1 more source

Profile likelihood analysis for a stochastic model of diffusion in heterogeneous media. [PDF]

open access: yesProc Math Phys Eng Sci, 2021
Simpson MJ   +5 more
europepmc   +1 more source

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