Results 51 to 60 of about 327,047 (257)

Uncertainty components in profile likelihood fits

European Physical Journal C: Particles and Fields
When a measurement of a physical quantity is reported, the total uncertainty is usually decomposed into statistical and systematic uncertainties. This decomposition is not only useful for understanding the contributions to the total uncertainty, but is ...
Andrés Pinto, Zhibo Wu, Fabrice Balli, Nicolas Berger, Maarten Boonekamp, Émilien Chapon, Tatsuo Kawamoto, Bogdan Malaescu   +7 more
doaj   +1 more source

Profile Likelihood and Baseline Sensitivity Diagnostics for Digitized Radiation Sensor Decay Datasets

Sensors
Accurate interpretation of radiation sensor decay data is important for environmental monitoring, site remediation, radiation metrology, detector quality assurance, and nuclear data evaluation. When the original gamma spectrometry records are unavailable,
Victor V. Golovko
doaj   +1 more source

Information Bias and Adjusted Profile Likelihoods

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1996
SUMMARY The bias and information bias of the ordinary profile score statistic are both typically of order O(1). Several additive adjustments to the profile score statistic that reduce its bias to order O(n  −1) have been proposed. In certain situations, the information bias of these adjusted profile score statistics is also reduced to ...
DiCiccio, Thomas J., Martin, Michael A., Stern, Steven E., Young, G. Alastair   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Improving soil moisture profile reconstruction from ground-penetrating radar data: a maximum likelihood ensemble filter approach [PDF]

Hydrology and Earth System Sciences, 2013
The vertical profile of shallow unsaturated zone soil moisture plays a key role in many hydro-meteorological and agricultural applications. We propose a closed-loop data assimilation procedure based on the maximum likelihood ensemble filter algorithm to ...
A. P. Tran, M. Vanclooster, S. Lambot
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Profile Likelihood and Conditionally Parametric Models

The Annals of Statistics, 1992
The authors outline a general approach to estimating the parametric component of a semiparametric model. For the case of a scalar parametric component the method is based on the idea of first estimating a one- dimensional subproblem of the original problem that is least favorable in the sense of \textit{C. Stein} [Proc. Third Berkeley Sympos.
Severini, Thomas A., Wong, Wing Hung
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source