Results 131 to 140 of about 327,047 (257)
Profile Likelihoods on ML-Steroids
Profile likelihoods, for instance, describing global SMEFT analyses at the LHC are numerically expensive to construct and evaluate. Especially profiled likelihoods are notoriously unstable and noisy. We show how modern numerical tools, similar to neural importance sampling, lead to a huge numerical improvement and allow us to evaluate the complete ...
Heimel, Theo +2 more
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Properties and Inference for Proportional Hazard Models
Revista Colombiana de Estadística, 2013 We consider an arbitrary continuous cumulative distribution function F(x) with a probability density function f(x) = dF(x)/dx and hazard function h f(x)=f(x)/[1-F(x)].
GUILLERMO MARTÍNEZ-FLÓREZ +2 more
doaj
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Semiparametric profile likelihood estimation for continuous outcomes with excess zeros in a random-threshold damage-resistance model. [PDF]
Stat Med, 2017 Rice JD, Tsodikov A.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Evaluating Testing, Profile Likelihood Confidence Interval Estimation, and Model Comparisons for Item Covariate Effects in Linear Logistic Test Models. [PDF]
Appl Psychol Meas, 2017 Cho SJ, De Boeck P, Lee WY.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Evolving Improved Sampling Protocols for Dose-Response Modelling Using Genetic Algorithms with a Profile-Likelihood Metric. [PDF]
Bull Math BiolLam NN, Murray R, Docherty PD.
europepmc +1 more source